Infection with Anthroponotic Cryptosporidium parvum does not fully protect the host against a subsequent challenge with C. hominis

Publication date: Available online 31 January 2018
Source:Microbes and Infection
Author(s): Abhineet S. Sheoran, Ruby Pina-Mimbela, Alison Keleher, Donald Girouard, Saul Tzipori
Cryptosporidium hominis and C. parvum are the major Cryptosporidium species that infect humans. Earlier studies in gnotobiotic piglets, model susceptible to both, showed that piglets recovered from infection with C. hominis were fully protected against challenge with same species but incompletely protected against C. parvum challenge. In the present study, piglets were infected with C. parvum first, and after recovery were re-challenged with C. parvum or C. hominis. Again, full protection was only observed when piglets were challenged with the homologous parasite strain. Although the two species are genetically/antigenically almost identical, they do not confer complete protection against each other.



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