Antifungal Photodynamic Inactivation against Dermatophyte Trichophyton rubrum Using Nanoparticle-Based Hybrid Photosensitizers

Publication date: Available online 23 June 2018
Source:Photodiagnosis and Photodynamic Therapy
Author(s): Niranga Wijesiri, Zhao Yu, Hong Tang, Peng Zhang
Trichophyton rubrum is one of the most common dermatophytes, which can cause fungal nail and ringworm infections. Infections associated with T. rubrum have become a global phenomenon. Herein, we report the antifungal photodynamic inactivation of T. rubrum (ATCC 28188) using the mesoporous silica-coated silver nanoparticle-based hybrid photosensitizers without involving antifungal drugs. Results show that the hybrid photosensitizers display low cytotoxicity under the experimental conditions where significant killing (~3 orders of magnitude) against T. rubrum is observed. These results demonstrate the potential applications of the nanoparticle-based hybrid photosensitizers in antifungal photodynamic therapy against T. rubrum.



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