Transgenic Artifacts Caused by Passenger Human Growth Hormone

Publication date: Available online 18 June 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Geoffroy de Faudeur, Bas Brouwers, Frans Schuit, John W.M. Creemers, Bruno Ramos-Molina
The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here the mouse lines in which ectopic hGH has been confirmed, and we provide a wiki for lines awaiting analysis.



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