Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters

Publication date: 3 July 2018
Source:Cell Metabolism, Volume 28, Issue 1
Author(s): Hong Jiang, Jens C. Brüning
In contrast to synaptic transmission, the mechanism of volume transmission—in which neurotransmitters or neuropeptides diffuse to many effector cells—is not extensively investigated, although it represents an important mode of neuronal communication. In this issue of Cell Metabolism, Noble et al. (2018) demonstrate how the orexigenic melanin-concentrating hormone (MCH) controls feeding behavior through cerebrospinal fluid (CSF) volume transmission.

Teaser

In contrast to synaptic transmission, the mechanism of volume transmission—in which neurotransmitters or neuropeptides diffuse to many effector cells—is not extensively investigated, although it represents an important mode of neuronal communication. In this issue of Cell Metabolism, Noble et al. (2018) demonstrate how the orexigenic melanin-concentrating hormone (MCH) controls feeding behavior through cerebrospinal fluid (CSF) volume transmission.


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