Synthesis and Biological Evaluation of a D-Ring-contracted Analogue of Lamellarin D

Publication date: Available online 9 February 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Vanessa Colligs, Steven Peter Hansen, Dennis Imbri, Ean-Jeong Seo, Onat Kadioglu, Thomas Efferth, Till Opatz
A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.

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