Dietary Fat Inflames CD4+ T Cell Memory in Obesity

Publication date: 7 March 2017
Source:Cell Metabolism, Volume 25, Issue 3
Author(s): Nicole M. Chapman, Hongbo Chi
T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling.

Teaser

T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism, Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling.


http://ift.tt/2mScNrU