Voxel-based logistic analysis of PPMI control and Parkinson's disease DaTscans

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Hemant D. Tagare, Christine DeLorenzo, Sudhakar Chelikani, Lawrence Saperstein, Robert K. Fulbright
A comprehensive analysis of the Parkinson's Progression Markers Initiative (PPMI) Dopamine Transporter Single Photon Emission Computed Tomography (DaTscan) images is carried out using a voxel-based logistic lasso model. The model reveals that sub-regional voxels in the caudate, the putamen, as well as in the globus pallidus are informative for classifying images into control and PD classes. Further, a new technique called logistic component analysis is developed. This technique reveals that intra-population differences in dopamine transporter concentration and imperfect normalization are significant factors influencing logistic analysis. The interactions with handedness, sex, and age are also evaluated.



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