A Dual Binding Receptor for ER-phagy

Publication date: 22 January 2018
Source:Developmental Cell, Volume 44, Issue 2
Author(s): Noboru Mizushima
Selective autophagy of the endoplasmic reticulum (ER)—ER-phagy—is mediated by multiple receptors. In this issue of Developmental Cell, Smith et al. (2018) identify ER membrane protein CCPG1 as an ER-phagy receptor that interacts with autophagy-related proteins GABARAPs and FIP200 and ensures ER protein homeostasis, especially in pancreatic acinar cells.

Teaser

Selective autophagy of the endoplasmic reticulum (ER)—ER-phagy—is mediated by multiple receptors. In this issue of Developmental Cell, Smith et al. (2018) identify ER membrane protein CCPG1 as an ER-phagy receptor that interacts with autophagy-related proteins GABARAPs and FIP200 and ensures ER protein homeostasis, especially in pancreatic acinar cells.


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