Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Publication date: 20 March 2018
Source:Immunity, Volume 48, Issue 3
Author(s): Elizabeth M. Steinert, Navdeep S. Chandel
Memory CD8⁺ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8⁺ T cells to produce IFN-γ.

Teaser

Memory CD8⁺ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8⁺ T cells to produce IFN-γ.


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