Multifunctional manganese-doped Prussian blue nanoparticles for two-photon photothermal therapy and magnetic resonance imaging

Publication date: June 2018
Source:Photodiagnosis and Photodynamic Therapy, Volume 22
Author(s): Lamiaa M.A. Ali, Emna Mathlouthi, Marilyn Kajdan, Morgane Daurat, Jérôme Long, Rahima Sidi-Boulenouar, Maïda Cardoso, Christophe Goze-Bac, Nourredine Amdouni, Yannick Guari, Joulia Larionova, Magali Gary-Bobo
Here we demonstrate for the first time that Mn²⁺-doped Prussian blue nanoparticles of c.a. 70 nm act as effective agents for photothermal therapy under two-photon excitation with an almost total eradication of malignant cells (97 and 98%) at a concentration of 100 μg mL⁻¹ 24 h after NIR excitation. This effect combined with interesting longitudinal NMR relaxivity values offer new perspectives for effective imaging and cancer treatment.

Graphical abstract

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