The Relation between Protein Z Polymorphism and the Risk of Thrombosis in Egyptian Patients with Antiphospholipid Syndrome

Publication date: Available online 17 April 2018
Source:Hematology/Oncology and Stem Cell Therapy
Author(s): Yomna K. Eissa, Hend N. Ellithy, Sherif M. Yousry, Zakaria Ismail
BackgroundThe genetic background plays an important role in thrombosis and pregnancy morbidities. Low levels of protein Z is associated with increased risk of thrombosis. The G79A polymorphism in the protein Z gene may be a genetic risk factor for thrombosis.Aim of the studyTo investigate the prevalence and clinical significance of the protein Z-79 G/A gene polymorphism in Egyptian patients with antiphospholipid syndrome (APS).MethodsWe genotyped 60 APS patients and 41 controls, for protein Z-79 G/A gene polymorphism using the PCR-restriction fragment length. The polymorphism was then analyzed in relation to thrombosis and pregnancy morbidities in APS patients.ResultsWe observed a higher prevalence of the A allele in the controls when compared to the APS patients (P Value= <0.001).In our studied sample, the G79A polymorphism, as well as its minor A allele, were not associated with an increased risk of thrombosis or pregnancy morbidities in APS.ConclusionProtein Z-79 G/A gene polymorphism may be of a protective value against thrombosis in APS. The G79A polymorphism of protein Z was not found to be an independent risk factor of thrombosis in APS.



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