Tufted angioma‐like lesion associated with VEGF and IL‐6 in TAFRO syndrome: Is it a common histological feature of multicentric Castleman disease/POEMS syndrome?

The histology of skin lesions of TAFRO (thrombocytopenia, anasarca, reticulin fibrosis/renal failure, and organomegaly) syndrome has rarely been reported. We report herein 2 cases of TAFRO syndrome with characteristic vascular skin lesions. The lesions resembled a tufted angioma (TA), although those of case 1 partially resembled a glomeruloid hemangioma, which was known as a specific lesion in POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M‐protein and skin changes), a variant of multicentric Castleman disease (MCD). The high titer of serum Vascular Endothelial Growth Factor (VEGF) and Interleukin‐6 (IL‐6) could explain common characteristic vascular lesions in both TAFRO syndrome and POEMS syndrome/MCD.

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