Necroptosis: (Last) Message in a Bubble

Publication date: 18 July 2017
Source:Immunity, Volume 47, Issue 1
Author(s): Peter Vandenabeele, Franck Riquet, Benjamin Cappe
RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports—in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)—reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.

Teaser

RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports—in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)—reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.


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