IMPACT OF DNA REPAIR, FOLATE AND GLUTATHIONE GENE POLYMORPHISMS ON RISK OF NON-SMALL CELL LUNG CANCER.

Publication date: Available online 21 November 2017
Source:Pathology - Research and Practice
Author(s): Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Ahmed Alnatsha, Eduardo Villar, Juan Ramón Delgado, Miguel Ángel Calleja-Hernández, María José Faus-Dáder
Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC.No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.



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