Objective: Prognosis of patients with metastatic melanoma has dramatically improved over recent years because of the advent of antibodies targeting programmed cell death protein-1 (PD1). However, the response rate is ~40% and baseline biomarkers for the outcome are yet to be identified. Here, we aimed to determine whether artificial intelligence might be useful in weighting the importance of baseline variables in predicting response to anti-PD1. Methods: This is a retrospective study evaluating...
Fri Jun 28, 2019 03:00
The prognosis of colorectal cancer (CRC) patients can be influenced by genetic mutations and nutritional status. The relationship between these variables is unclear. The objective of the study was to verify th...
Sat Jun 29, 2019 03:00
The optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the clinical value and complications of segm...
Fri Jun 28, 2019 03:00
Delivering widespread BRCA testing to patients with ovarian cancer has been suggested by several scientists, recommended by professional societies and solicited by patients organizations. However, based on the...
Fri Jun 28, 2019 03:00
Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...
Fri Jun 28, 2019 03:00
To evaluate the outcome of patients treated with stereotactic ablative body radiotherapy (SABR) with curative intent for stage I non-small cell lung cancer (NSCLC) with regard to local, regional and distant tu...
Fri Jun 28, 2019 03:00
Puerto Rico has the highest incidence rate of thyroid cancer (TC) in the Americas and the third highest rate worldwide. The purpose of this study was to compare the burden of TC between the population of PR an...
Fri Jun 28, 2019 03:00
Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and t...
Thu Jun 27, 2019 03:00
Zinc-finger E-box binding homeobox 1 (ZEB-1) plays crucial roles in epithelial-to-mesenchymal transition during tumor carcinogenesis. Published studies have examined the potential value of ZEB-1 as a biomarker...
Thu Jun 27, 2019 03:00
British Journal of Cancer, Published online: 01 July 2019; doi:10.1038/s41416-019-0480-zThe arrival of biosimilar monoclonal antibodies in oncology: clinical studies for trastuzumab biosimilars
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Mahase reports that doctors will be able to halve pension contributions to ease tax burden.1 I won’t hold my breath. A consultation will start at the end of June. Meanwhile, many doctors are worried...
Fri Jun 28, 2019 18:36
Digital first GP providers such as Babylon’s GP at Hand should have to establish a physical location and to contract in all areas where they serve large numbers of patients, to protect efforts to...
Fri Jun 28, 2019 17:41
We thank Crawford for his constructive response to our article.12 His argument—that changes to the organisation and delivery of care should undergo rigorous evaluation, with a focus on effects on...
Fri Jun 28, 2019 16:41
The BMA appointed a non-executive member of its risk and audit committee in April to lead a review of historical expense claims and policies, the association has disclosed.The news that Jacques...
Fri Jun 28, 2019 16:36
What you need to knowIncidence rate of syphilis have increased substantially around the world, mostly affecting men who have sex with men and people infected with HIVHave a low index of suspicion for...
Fri Jun 28, 2019 16:26
Imagine comprehensive community based healthcare, where more patients can receive specialist advice locally, without having to go to a hospital. Where ongoing training enables generalists to develop...
Fri Jun 28, 2019 16:25
Fulop and Ramsay describe how organisations can drive changes in practice that can improve care.1 Their underlying assumption is that all such change is beneficial.All humans are capable of self...
Fri Jun 28, 2019 15:11
Background Checkpoint inhibitors have shown modest activity in patients with advanced hepatocellular carcinoma (HCC). Herein, the authors report a prospective single‐institution clinical/translational phase 2 study of pembrolizumab in patients with advanced HCC and circulating biomarkers closely related to response. Methods Pembrolizumab was administered at a dose of 200 mg intravenously every 3 weeks among patients who may have developed disease progression while receiving, were intolerant...
Fri Jun 28, 2019 17:00
Fri Jun 28, 2019 16:59
Background There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population‐based analysis of long‐term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of...
Fri Jun 28, 2019 16:54
Background Curative therapy places childhood cancer survivors at increased risk for second primary malignancies (SPMs). However, there have been few population‐based attempts to characterize differences between outcomes of SPMs in childhood cancer survivors and outcomes of first primary malignancies (FPMs). Methods Clinical and demographic information about childhood cancer survivors who developed SPMs and individuals with comparable FPMs was extracted from the Surveillance, Epidemiology,...
Fri Jun 28, 2019 16:50
Background Patients with anaplastic glioma (AG) harboring an isocitrate dehydrogenase mutation have potential durable survival after intensity‐modulated radiotherapy (IMRT) and chemotherapy. Understanding long‐term functioning, and the factors that have an impact on later effects, is important for decision making. Methods Consecutive patients with AG who received IMRT were reviewed with regard to 6 survivorship domains, including Eastern Cooperative Oncology Group (ECOG) performance status,...
Fri Jun 28, 2019 16:49
Background Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative management for LRPC and associated short‐term outcomes in young versus older men in the United States. Methods The nonpublic Surveillance, Epidemiology, and End Results Prostate with Active Surveillance/Watchful...
Fri Jun 28, 2019 16:48
Mounting evidence has shown that long noncoding RNAs (lncRNAs) can play a substantial role in gallbladder cancer (GBC) development as tumor promotors or suppressors, and their abnormal expression is relevant t...
Fri Jun 28, 2019 03:00
Caveolin-1 (Cav-1) plays an important role in the development of various human cancers. We investigated the relationship between Cav-1 expression and non-small cell lung cancer (NSCLC) progression in the conte...
Fri Jun 28, 2019 03:00
Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets. We aimed to explore some novel gene...
Fri Jun 28, 2019 03:00
The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential t...
Fri Jun 28, 2019 03:00
Cancer Gene Therapy, Published online: 01 July 2019; doi:10.1038/s41417-019-0117-7Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF4E/PUMA pathway
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