Nucleotide supply is essential for DNA replication in proliferating cells including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. PRPS1 participates in the pentose phosphate pathway (PPP) by catalyzing the phospho-ribosylation of D-ribose 5-phosphate (R-5P) to 5-phosphoribosyl-1-pyrophosphate (PRPP). Therefore, PRPS1 not only controls purine biosynthesis and supplies precursors for DNA and RNA biosynthesis but...
Fri Jun 28, 2019 15:45
Emerging evidence suggests a role of psychological factors in the progression of different cancer types. However, it is unclear whether psychological distress around the time of diagnosis of invasive cervical cancer places patients at a higher risk of cancer-specific mortality, independently of tumor characteristics and treatment modalities. We conducted a nationwide cohort study, including 4,245 patients with newly diagnosed cervical cancer during 2002-2011 in Sweden. Psychological distress was...
Fri Jun 28, 2019 15:45
Abstract Previous studies showed sex differences in incidence of adverse events by fluoropyrimidines, the mechanism of the difference has been unknown enough. We examined for sex differences in safety of S‐1 plus oxaliplatin (SOX) and S‐1 plus cisplatin (CS) in 663 metastatic gastric cancer patients from a phase III study. Leukopenia (odds ratio [OR] 1.9; P=0.015), neutropenia (OR 2.2; P=0.002), nausea (OR 2.0; P=0.009), and vomiting (OR 2.8; P<0.001) were increased in females treated with SOX,...
Sat Jun 29, 2019 17:49
Abstract Bladder cancer (BC) is the most common neoplasm affecting the urinary tract in human and dogs. Since dog BC resembles muscle‐invasive BC in human with regards to histopathological characteristics and gene expression profiles, it is expected to become a precious research model of human muscle‐invasive BC. Cancer patient‐derived organoid culture can recapitulate organ structures and maintain gene expression profiles of original tumor tissues. In the previous study, we generated dog prostate...
Sat Jun 29, 2019 17:02
Abstract Senescence is a state of growth arrest induced in not only normal cells but also cancer cells by aging or stress, which triggers DNA damage. Despite growth suppression, senescent cancer cells promote tumor formation and recurrence by producing cytokines and growth factors; this state is designated as the senescence‐associated secretory phenotype (SASP). In this study, we examined the susceptibility of senescent human breast cancer cells to immune cell‐mediated cytotoxicity. Doxorubicin...
Fri Jun 28, 2019 12:19
The FDA approved daratumumab in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. (Source: CancerNetwork)
Fri Jun 28, 2019 06:00
Cancers, Vol. 11, Pages 921: Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor Cancers doi: 10.3390/cancers11070921 Authors: Ricarda Hannen Martin Selmansberger Maria Hauswald Axel Pagenstecher Andrea Nist Thorsten Stiewe Till Acker Barbara Carl Christopher Nimsky Jörg Walter Bartsch About 95% of patients with Glioblastoma...
Sun Jun 30, 2019 03:00
Cancers, Vol. 11, Pages 920: Is the Blood an Alternative for Programmed Cell Death Ligand 1 Assessment in Non-Small Cell Lung Cancer? Cancers doi: 10.3390/cancers11070920 Authors: Emmanuel Acheampong Isaac Spencer Weitao Lin Melanie Ziman Michael Millward Elin Gray Anti-programmed cell death (PD)-1/PD-ligand 1 (L1) therapies have significantly improved the outcomes for non-small cell lung cancer (NSCLC) patients in recent years. These therapies work by reactivating the...
Sun Jun 30, 2019 03:00
Cancers, Vol. 11, Pages 919: The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro Cancers doi: 10.3390/cancers11070919 Authors: Femke Verhees Dion Legemaate Imke Demers Robin Jacobs Wisse Evert Haakma Mat Rousch Bernd Kremer Ernst Jan Speel Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy of...
Sun Jun 30, 2019 03:00
Cancers, Vol. 11, Pages 917: DNA-Repair Gene Mutations Are Highly Prevalent in Circulating Tumour DNA from Multiple Myeloma Patients Cancers doi: 10.3390/cancers11070917 Authors: Sridurga Mithraprabhu Jay Hocking Malarmathy Ramachandran Kawa Choi Daniela Klarica Tiffany Khong John Reynolds Andrew Spencer Mutational characterisation utilising plasma (PL)-derived circulating tumour DNA (ctDNA) in multiple myeloma (MM) has been recently described. Mutational analyses...
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 918: Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells Cancers doi: 10.3390/cancers11070918 Authors: Liu Yu-Chun Chang Kuo Chen Hsu Tu Yeh Viswanadha Liao Huang Hepatocellular carcinoma (HCC) is a common fatal type of malignant tumor that has highly metastatic and recurrent properties....
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 916: Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells Cancers doi: 10.3390/cancers11070916 Authors: Christopher Nguyen Siyaram Pandey The transformation of normal cells to the cancerous stage involves multiple genetic changes or mutations leading to hyperproliferation, resistance to apoptosis, and evasion of the host immune system. However, to accomplish hyperproliferation, cancer cells undergo profound metabolic reprogramming...
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 915: Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical Application Cancers doi: 10.3390/cancers11070915 Authors: Mulder Wahlin Österborg Palma In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma...
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 914: Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer Cancers doi: 10.3390/cancers11070914 Authors: Alba Loras M. Carmen Martínez-Bisbal Guillermo Quintás Salvador Gil Ramón Martínez-Máñez José Luis Ruiz-Cerdá Patients with non-muscle invasive bladder cancer (NMIBC) undergo lifelong monitoring based on repeated cystoscopy and urinary cytology due to the high recurrence rate of this tumor. Nevertheless, these...
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 913: Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro Cancers doi: 10.3390/cancers11070913 Authors: Jana Konířová Lukáš Cupal Šárka Jarošová Anna Michaelidesová Jana Vachelová Marie Davídková Petr Bartůněk Martina Zíková Radiotherapy plays a significant role in brain cancer treatment; however, the use of this therapy is often accompanied by neurocognitive decline that is, at least partially, a consequence...
Sat Jun 29, 2019 03:00
Cancers, Vol. 11, Pages 911: Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic Inflammation Cancers doi: 10.3390/cancers11070911 Authors: Sandra Romero-Cordoba Elisabetta Meneghini Milena Sant Marilena Valeria Iorio Lucia Sfondrini Biagio Paolini Roberto Agresti Elda Tagliabue Francesca Bianchi Triple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. New opportunities are emerging...
Fri Jun 28, 2019 03:00
Cancers, Vol. 11, Pages 910: Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1 Cancers doi: 10.3390/cancers11070910 Authors: Xiaoping Wang Chun Li Qiyan Wang Weili Li Dongqing Guo Xuefeng Zhang Mingyan Shao Xu Chen Lin Ma Qian Zhang Wei Wang Yong Wang Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation...
Fri Jun 28, 2019 03:00
Cancers, Vol. 11, Pages 912: Whole-blood DNA Methylation Markers for Risk Stratification in Colorectal Cancer Screening: A Systematic Review Cancers doi: 10.3390/cancers11070912 Authors: Raut Guan Schrotz-King Brenner DNA methylation profiles within whole-blood samples have been reported to be associated with colorectal cancer (CRC) occurrence and might enable risk stratification for CRC. We systematically reviewed and summarized studies addressing the association of whole-blood...
Fri Jun 28, 2019 03:00
Abstract Background Malignant melanoma is a well-known and commonly lethal tumour yet there exists scarce published information available from Saudi Arabia. Materials and methods This study examined the demographic, clinical, and histopathological profile of melanoma in a sample of Saudi patients over a period of 13 years. Medical records of 98 patients from...
Sat Jun 29, 2019 03:00
Abstract Purpose There is limited evidence on the efficacy and safety of anti-programmed cell death protein 1 (PD-1)-/anti-programmed death-ligand 1 (PD-L1)-based immunotherapy in the elderly, particularly those aged over 75 years. Methods/patients The clinical response and toxicity profile of anti-PD-1-/anti-PD-L1-based immunotherapy in patients aged over...
Sat Jun 29, 2019 03:00
Abstract Purpose To determine whether cytomegalovirus is causally associated with breast cancer and whether cytomegalovirus should be categorised as an oncogenic virus. Methods We undertook a review of published epidemiological and laboratory studies, using established causal criteria: Bradford Hill criteria to determine whether cytomegalovirus is associated...
Sat Jun 29, 2019 03:00
Abstract Radiation acts not only through cell death but has also angiogenic, immunomodulatory and bystander effects. The realization of its systemic implications has led to extensive research on the combination of radiotherapy with systemic treatments, including immunotherapy and antiangiogenic agents. Parameters such as dose, fractionation and sequencing of treatments are key determinants of the outcome. However, recent high-quality research indicates that these are not the only...
Fri Jun 28, 2019 03:00
Abstract Purpose Immunotherapy is a new standard first-line treatment for non-small cell lung cancers (NSCLC) with high programmed cell death-ligand 1 (PD-L1) expression (≥ 50%) and second-line treatment regardless of PD-L1 status, though not all patients benefit from this approach. Much effort is ongoing to identify robust prognostic and predictive biomarkers of response to immune checkpoint inhibitors, overcoming PD-L1 that appears limited...
Fri Jun 28, 2019 03:00
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