Abstract Objective The possible etiological relationship of the vitamin D with laryngomalacia is unclear. The aim of the study was to demonstrate the relationship between laryngomalacia and vitamin D levels. Methods Twenty-three non-syndromic babies under the age of 1 year who were diagnosed with laryngomalacia were included in the study group. Forty healthy...
Wed Oct 07, 2020 03:00
Abstract Purpose In patients with obesity, micronutrient deficiencies have been reported both before and after bariatric surgery (BS). Obesity is a chronic pro-inflammatory status, and inflammation increases the risk of micronutrient malnutrition. Our objective was to assess in pre-BS patients the prevalence of micronutrient deficiencies and their correlation with blood values of C-reactive protein (CRP). ...
Wed Oct 07, 2020 03:00
The Pacific white shrimp, with the largest production in shrimp industry, has suffered from multiple severe viral and bacterial diseases, which calls for a more reliable and environmentally friendly system to ...
Tue Oct 06, 2020 03:00
Analysis with biological nanopore: On-pore, off-pore strategies and application in biological fluids
Publication date: 1 February 2021Source: Talanta, Volume 223, Part 1Author(s): Yunjiao Wang, Youwen Zhang, Xiaohan Chen, Xiyun Guan, Liang Wang
Wed Oct 07, 2020 12:21
Publication date: 1 February 2021Source: Talanta, Volume 223, Part 1Author(s): Siqiao Li, Zhengwei Zhang
Wed Oct 07, 2020 12:21
Publication date: 1 February 2021Source: Talanta, Volume 223, Part 1Author(s): Anle Ge, Liang Hu, JiaXing Fan, Minghai Ge, Xixian Wang, Shanshan Wang, Xiaojun Feng, Wei Du, Bi-Feng Liu
Wed Oct 07, 2020 12:21
Publication date: 1 February 2021Source: Talanta, Volume 223, Part 1Author(s): Olesya Daikos, Mirko Naumann, Katrin Ohndorf, Carsten Bundesmann, Ulrike Helmstedt, Tom Scherzer
Wed Oct 07, 2020 12:21
Related Articles Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment. Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):8148-8157 Authors: Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P Abstract OBJECTIVE: The aim of this review is to describe the "hot points" of current clinical governance for oral HPV comprising the use of new diagnostic...
Wed Oct 07, 2020 13:06
Related Articles Current management of congenital anterior cranial base encephaloceles. Int J Pediatr Otorhinolaryngol. 2020 Apr;131:109868 Authors: Thompson HM, Schlosser RJ, McCarty Walsh E, Cho DY, Grayson JW, Karnezis TT, Miller PL, Woodworth BA Abstract OBJECTIVES: Congenital encephaloceles provide unique diagnostic and reconstructive challenges for the pediatric rhinologist. The objectives of the current study were to evaluate contemporary...
Wed Oct 07, 2020 13:06
Related Articles Can endoscopic ear surgery replace microscopic surgery in the treatment of acquired cholesteatoma? A contemporary review. Int J Pediatr Otorhinolaryngol. 2020 Apr;131:109872 Authors: Hu Y, Teh BM, Hurtado G, Yao X, Huang J, Shen Y Abstract Acquired cholesteatoma leads to significant morbidities while current surgical options remain a challenge. The principles of surgery include complete removal of disease, prevention of recurrence,...
Wed Oct 07, 2020 13:06
Related Articles Preoperative platelet-lymphocyte ratio predicts recurrence of laryngeal squamous cell carcinoma. Future Oncol. 2020 Feb;16(6):209-217 Authors: Chen H, Song S, Zhang L, Dong W, Chen X, Zhou H Abstract Aim: To evaluate the impact of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived NLR (dNLR) and lymphocyte-monocyte ratio (LMR) on the prognosis of laryngeal squamous cell carcinoma. Materials...
Wed Oct 07, 2020 13:06
Related Articles Pull-through resection without free-flap reconstruction for lateral wall oropharyngeal cancer. Jpn J Clin Oncol. 2020 Sep 05;50(9):1018-1022 Authors: Matsumoto F, Kobayashi K, Omura G, Matsumura S, Matsumoto Y, Fukasawa M, Yoshimoto S Abstract BACKGROUND: While transoral robotic surgery (TORS) is widely used for the management of lateral wall oropharyngeal carcinomas (OPC), open surgical techniques are still used in some cases....
Wed Oct 07, 2020 13:06
Methodology and technology for the development of a prognostic MRI-based radiomic model for the outcome of head and neck cancer patients. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:1152-1155 Authors: Bologna M, Corino V, Tenconi C, Facchinetti N, Calareso G, Iacovelli N, Cavallo A, Alfieri S, Cavalieri S, Fallai C, Valdagni R, Rancati T, Trama A, Licitra L, Orlandi E, Mainardi L Abstract The purpose of this study was to establish...
Wed Oct 07, 2020 13:06
The association between the composite quality measure "textbook outcome" and long term survival in operated colon cancer. Medicine (Baltimore). 2020 Oct 02;99(40):e22447 Authors: Yang CC, Tian YF, Liu WS, Chou CL, Cheng LC, Chu SS, Lee CC Abstract The aim of this study was to investigate the relationship between textbook outcome and survival in patients with surgically treated colon cancer. A total of 804 surgical cases were enrolled between...
Wed Oct 07, 2020 13:06
Mast Cells in the Auditory Periphery of Rodents. Brain Sci. 2020 Oct 01;10(10): Authors: Szczepek AJ, Dudnik T, Karayay B, Sergeeva V, Olze H, Smorodchenko A Abstract Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never...
Wed Oct 07, 2020 13:06
c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair. Int J Mol Sci. 2020 Oct 01;21(19): Authors: Deville SS, Delgadillo Silva LF, Vehlow A, Cordes N Abstract The intermediate filament synemin has been previously identified as novel regulator of cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase...
Wed Oct 07, 2020 13:06
Impact of COVID-19 Pandemic on Ambulatory and Operating Room Rhinology Practice in the US. Am J Rhinol Allergy. 2020 Oct 05;:1945892420961962 Authors: Papagiannopoulos P, Ganti A, Kim YJ, Raad RA, Kuan EC, Losavio P, Tajudeen BA, Batra PS Abstract INTRODUCTION: The pandemic caused by the novel coronavirus virus has altered all facets of clinical practice in the United States. The goal of this study is to better understand the impact of...
Wed Oct 07, 2020 13:06
Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes. Am J Rhinol Allergy. 2020 Oct 05;:1945892420964054 Authors: Li W, Lu H, Wang H, Zhang H, Sun X, Hu L, Zhao W, Gu Y, Li H, Wang D Abstract BACKGROUND: This study aimed to investigate the demographics, treatment outcomes, and prognostic factors of salvage endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma...
Wed Oct 07, 2020 13:06
Comparison of clinical outcome between endoscopic and postauricular incision microscopic type-1 tympanoplasty. Acta Otolaryngol. 2020 Oct 06;:1-5 Authors: Zhang Y, Wang W, Xu K, Hu M, Ma Y, Lin P Abstract BACKGROUND: Microscopic type-1 tympanoplasty (T1T) is a classical method for the treatment of chronic otitis media. However, it has its limitations. The development of otoendoscopy provided a new method for T1T. OBJECTIVE: To...
Wed Oct 07, 2020 13:06
Drug-related problems in head and neck cancer patients identified by repeated medication reviews on consecutive therapy cycles. J Oncol Pharm Pract. 2020 Oct 06;:1078155220962178 Authors: Vucur C, Wirtz DA, Weinhold L, Zipfel M, Schmid M, Schmidt-Wolf IG, Jaehde U Abstract BACKGROUND: Head and neck cancer (HNC) patients are particularly vulnerable to drug-related problems (DRPs) given the toxicity of concomitant chemoradiotherapy (CCRT)....
Wed Oct 07, 2020 13:06
Multi-institutional Evaluation of Radiologic Findings Associated With Pediatric Congenital Idiopathic Bilateral Vocal Fold Dysfunction. Otolaryngol Head Neck Surg. 2020 Oct 06;:194599820961109 Authors: Ruda J, Dahl J, McClain W, Drake A, Rubel K, Onwuka A, Krakovitz P, Anne S Abstract OBJECTIVE: To report brain magnetic resonance imaging (MRI) and ultrasonography findings in pediatric patients with congenital idiopathic bilateral vocal...
Wed Oct 07, 2020 13:06
The Potential for Telemedicine to Reduce Bias in Patients Seeking Facial Plastic Surgery. Otolaryngol Head Neck Surg. 2020 Oct 06;:194599820964731 Authors: Salehi PP, Wong BJF, Azizzadeh B Abstract Telemedicine use among otolaryngologists-head and neck surgeons and facial plastic and reconstructive surgeons has accelerated as a result of the COVID-19 pandemic. Yet, it is unclear what impact the increased adoption of telehealth will have...
Wed Oct 07, 2020 13:06
Multi-institutional Comparison of Temporal Bone Models: A Collaboration of the AAO-HNSF 3D-Printed Temporal Bone Working Group. Otolaryngol Head Neck Surg. 2020 Oct 06;:194599820960474 Authors: Mowry SE, Jabbour N, Rose AS, Wiet GJ, Svrakic M, Zopf DA, Vankoevering K, Powell A, Freiser ME, Hochman J, Smith R Abstract OBJECTIVE: The American Academy of Otolaryngology-Head and Neck Surgery Foundation's (AAO-HNSF's) 3D-Printed Temporal Bone...
Wed Oct 07, 2020 13:06
Role of Vitamin D Supplements in Prevention of Hungry Bone Syndrome after Successful Parathyroidectomy for Primary Hyperparathyroidism: A Prospective Study. Scand J Surg. 2020 Oct 06;:1457496920962601 Authors: Salman MA, Rabiee A, Salman A, Youssef A, E-D Shaaban H, Ftohy TE, Maurice KK, Balamoun H Abstract BACKGROUND: We postulated that the preoperative correction of vitamin D levels can significantly reduce the incidence of hunger bone...
Wed Oct 07, 2020 13:06
SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma.
SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma. Biochem Biophys Res Commun. 2020 Oct 03;: Authors: Hémon A, Louandre C, Lailler C, Godin C, Bottelin M, Morel V, François C, Galmiche A, Saidak Z Abstract Ferroptosis, a regulated form of cell necrosis was previously reported to be induced upon pharmacological targeting of the cystine transporter SLC7A11 in Head and neck Squamous Cell Carcinoma...
Wed Oct 07, 2020 13:06
Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and 'Moderately differentiated' Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and treatment decision-making. J Nucl Med Technol. 2020 Oct 05;: Authors: Sharma P, Basu S Abstract Metastatic neuroendocrine neoplasms (NEN) of the parotid gland, with discordant histopathology...
Wed Oct 07, 2020 13:06
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nat Commun. 2020 Oct 05;11(1):4980 Authors: Feng YC, Liu XY, Teng L, Ji Q, Wu Y, Li JM, Gao W, Zhang YY, La T, Tabatabaee H, Yan XG, Jamaluddin MFB, Zhang D, Guo ST, Scott RJ, Liu T, Thorne RF, Zhang XD, Jin L Abstract The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably...
Wed Oct 07, 2020 13:06
Otolaryngology Surgical Activity in Tertiary Care Center During the Covid-19 Lockdown. Indian J Otolaryngol Head Neck Surg. 2020 Oct 01;:1-6 Authors: Atru B, Sutrave M, George R, James R, Ross A, C B P Abstract Corona virus disease (COVID 19) is an infectious respiratory disease caused by the novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With many countries implementing lockdown the surgical activities in the...
Wed Oct 07, 2020 13:06
Otological aspects of NLRP3-related autoinflammatory disorder focusing on the responsiveness to anakinra. Rheumatology (Oxford). 2020 Oct 06;: Authors: Kim BJ, Kim YH, Lee S, Han JH, Lee SY, Seong J, Lee DH, Kim B, Park HR, Carandang M, Oh D, Oh SH, Kim JG, Lee S, Choi BY Abstract OBJECTIVES: Gradually progressive sensorineural hearing loss (SNHL) is a prevalent sensory defect. It is generally untreatable, making rehabilitation by hearing...
Wed Oct 07, 2020 13:06
The role of SCFSkp2 and SCFβ-TrCP1/2 in the cerebellar granule cell precursors. Genes Cells. 2020 Oct 06;: Authors: Yamashita M, Owa T, Shiraishi R, Adachi T, Ichijo K, Taya S, Miyashita S, Hoshino M Abstract A proper balance between proliferation and differentiation of cerebellar granule cell precursors (GCPs) is required for appropriate cerebellar morphogenesis. The Skp1-Cullin1-F-box (SCF) complex, an E3-ubiquitin ligase complex, is...
Wed Oct 07, 2020 13:06
An enhanced recovery program improves the comfort and outcomes in children with obstructive sleep apnea undergoing adenotonsillectomy：A retrospective historical control study. Clin Otolaryngol. 2020 Oct 05;: Authors: Zhang Y, Liu D, Chen X, Ma J, Song X Abstract OBJECTIVE: To explore the effects of an enhanced recovery after surgery (ERAS) program on postoperative rehabilitation in children with obstructive sleep apnea (OSA) during the...
Wed Oct 07, 2020 13:06
Volatile organic compound breath testing detects in-situ squamous cell carcinoma of bronchial and laryngeal regions and shows distinct profiles of each tumour. J Breath Res. 2020 Oct 06;14(4):046013 Authors: Fielding D, Hartel G, Pass D, Davis M, Brown M, Dent A, Agnew J, Dickie G, Ware RS, Hodge R Abstract Volatile organic compound (VOC) breath testing of lung and head and neck squamous cell carcinoma (SCC) has been widely studied, however...
Wed Oct 07, 2020 13:06
Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma. Head Neck. 2020 Oct 06;: Authors: Arun I, Maity N, Hameed S, Jain PV, Manikantan K, Sharan R, Arun P Abstract BACKGROUND: The prognostic significance of various histopathologic lymph node-based biomarkers in oral squamous cell carcinoma (OSCC) needs further evaluation. METHODS: Retrospective analysis of 212 OSCC patients with regional...
Wed Oct 07, 2020 13:06
Sleep Architecture in Children With Down Syndrome With and Without Obstructive Sleep Apnea. Otolaryngol Head Neck Surg. 2020 Oct 06;:194599820960454 Authors: Heubi CH, Knollman P, Wiley S, Shott SR, Smith DF, Ishman SL, Meinzen-Derr J Abstract OBJECTIVE: To characterize polysomnographic sleep architecture in children with Down syndrome and compare findings in those with and without obstructive sleep apnea. STUDY DESIGN: Case...
Wed Oct 07, 2020 13:06
Clinical Feature and Prognosis of Sudden Sensorineural Hearing Loss With Rheumatoid Arthritis. Otol Neurotol. 2020 Oct 05;: Authors: Li H, Zhang M, Wang M, Zhang S, Ma S, Wang X Abstract OBJECTIVES: Recent publications reported that patients with rheumatoid arthritis (RA) experience an increased risk of suffering sudden sensorineural hearing loss (SSNHL), however, these cases are poorly understood. This study aims to explore the clinical...
Wed Oct 07, 2020 13:06
Add-on effect of clarithromycin to oral steroids as post- operative therapy for chronic rhinosinusitis with nasal polyps: a randomised controlled trial. Rhinology. 2020 Oct 06;: Authors: Lin CF, Wang MC, Merton AT, Ho NH, Wu PS, Hsu AT, Wang YP Abstract BACKGROUND: Evidence is lacking regarding the efficacy of macrolides and oral corticosteroids in chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS)....
Wed Oct 07, 2020 13:06
Preoperative Misdiagnosis of Malignant Mucosal Melanoma of the Nasal Septum by MRI. Ear Nose Throat J. 2020 Oct 06;:145561320963566 Authors: Kim KS, Min HJ Abstract Malignant sinonasal mucosal melanoma is a rare and aggressive neoplasm. As it shows nonspecific clinical symptoms, magnetic resonance imaging (MRI) is the most effective diagnostic tool. Before a mass is histopathologically confirmed, MRI is regarded as the optimal differential...
Wed Oct 07, 2020 13:06
An Unhappy Shooting Star: A Laryngeal Foreign Body Masquerading as Croup. Ear Nose Throat J. 2020 Oct 06;:145561320962585 Authors: Hosokawa S PMID: 33021838 [PubMed - as supplied by publisher]
Wed Oct 07, 2020 13:06
Evaluating YouTube as a Source of Patient Information for Functional Endoscopic Sinus Surgery. Ear Nose Throat J. 2020 Oct 06;:145561320962867 Authors: Wu V, Lee DJ, Vescan A, Lee JM Abstract OBJECTIVE: To evaluate the quality of information presented on YouTube regarding functional endoscopic sinus surgery (FESS) for patients. METHODS: YouTube was searched using FESS-specific keywords under the setting of "relevance." The first...
Wed Oct 07, 2020 13:06
Development and Validation of the Nasal Outcome Score for Epistaxis in Hereditary Hemorrhagic Telangiectasia (NOSE HHT). JAMA Otolaryngol Head Neck Surg. 2020 Oct 01;: Authors: Peterson AM, Kallogjeri D, Spitznagel E, Chakinala MM, Schneider JS, Piccirillo JF Abstract Importance: Epistaxis is the greatest cause of morbidity in patients with hereditary hemorrhagic telangiectasia (HHT); because of this, a validated epistaxis-specific quality-of-life...
Wed Oct 07, 2020 13:06
Association Between Implementation of the 2009 American Thyroid Association Guidelines and De-escalation of Treatment for Low-risk Papillary Thyroid Carcinoma. JAMA Otolaryngol Head Neck Surg. 2020 Oct 01;: Authors: Lohia S, Morris LGT, Roman BR PMID: 33022058 [PubMed - as supplied by publisher]
Wed Oct 07, 2020 13:06
Otolaryngologic Management of Chronic Cough in School-aged Children: A Review. JAMA Otolaryngol Head Neck Surg. 2020 Oct 01;: Authors: Kennedy AA, Anne S, Hart CK Abstract Importance: The causes of pediatric chronic cough are numerous and span across several medical subspecialties. In addition to the vast array of underlying causes, there are also several different ways to approach and evaluate chronic cough. Given the frequency with which...
Wed Oct 07, 2020 13:06
Association Between Hearing Impairment and Postural Instability-Reply. JAMA Otolaryngol Head Neck Surg. 2020 Oct 01;: Authors: Bang SH, Kim AY, Chae SW PMID: 33022067 [PubMed - as supplied by publisher]
Wed Oct 07, 2020 13:06
Cerebrospinal Fluid Leak After Nasal Swab Testing for Coronavirus Disease 2019. JAMA Otolaryngol Head Neck Surg. 2020 Oct 01;: Authors: Sullivan CB, Schwalje AT, Jensen M, Li L, Dlouhy BJ, Greenlee JD, Walsh JE PMID: 33022069 [PubMed - as supplied by publisher]
Wed Oct 07, 2020 13:06
Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications. Laryngoscope. 2020 Oct 06;: Authors: Chang B, Cornett A, Nourmohammadi Z, Law J, Weld B, Crotts SJ, Hollister SJ, Lombaert IMA, Zopf DA Abstract OBJECTIVES/HYPOTHESIS: To analyze the use of highly translatable three-dimensional (3D)-printed auricular scaffolds with and without novel cartilage tissue inserts in a rodent model....
Wed Oct 07, 2020 13:06
Pediatric Post-Tonsillectomy Opioid Prescribing Practices. Laryngoscope. 2020 Oct 06;: Authors: Agamawi YM, Cass LM, Mouzourakis M, Pannu JS, Brinkmeier JV Abstract OBJECTIVE: To evaluate the effect of discharge order sets on prescribing patterns of opioids after pediatric tonsillectomy. Secondary outcomes included encounters for postoperative pain, dehydration, and bleeding. METHODS: Retrospective chart review of pre- and post-intervention...
Wed Oct 07, 2020 13:06
Effects of Fundamental Frequency Contours on Sentence Recognition in Mandarin-Speaking Children With Cochlear Implants. J Speech Lang Hear Res. 2020 Oct 06;:1-10 Authors: Huang W, Wong LLN, Chen F, Liu H, Liang W Abstract Purpose Fundamental frequency (F0) is the primary acoustic cue for lexical tone perception in tonal languages but is processed in a limited way in cochlear implant (CI) systems. The aim of this study was to evaluate the...
Wed Oct 07, 2020 13:06
Regular Application of Sunscreen Can Prevent Skin Cancer. J Cosmet Sci. 2020 Jul/Aug;71(4):191-198 Authors: AdÈle C G Abstract This review summarizes the evidence on the protection against skin cancer afforded by sunscreen. Solid evidence can come only from randomized controlled trials, despite a multitude of case-control and cohort studies that have addressed the issue, because observational evidence is intractably confounded since those...
Wed Oct 07, 2020 13:06
Association between night-shift work and level of melatonin: systematic review and meta-analysis. Sleep Med. 2020 Sep 19;75:502-509 Authors: Wei T, Li C, Heng Y, Gao X, Zhang G, Wang H, Zhao X, Meng Z, Zhang Y, Hou H Abstract BACKGROUNDS: Night-shift workers are exposed to nocturnal light and are more prone to circadian rhythm disorders. Although night-shift work is thought to be associated with the decrease in melatonin secretion, studies...
Wed Oct 07, 2020 13:06
Visualization of the morphology and pathology of the peripheral branches of the cranial nerves using three-dimensional high-resolution high-contrast magnetic resonance neurography. Eur J Radiol. 2020 Jun 20;132:109137 Authors: Wu W, Wu F, Liu D, Zheng C, Kong X, Shu S, Li D, Kong X, Wang L Abstract PURPOSE: To assess the feasibility and advantages of high-resolution high-contrast magnetic resonance neurography (HRHC-MRN) for visualizing...
Wed Oct 07, 2020 13:06
Incidence of cure and residual obstructive sleep apnea in obese children after tonsillectomy and adenoidectomy stratified by age group. Int J Pediatr Otorhinolaryngol. 2020 Sep 28;139:110394 Authors: Lee T, Wulfovich S, Kettler E, Nation J Abstract OBJECTIVES: Current clinical guidelines by the American Academy of Pediatrics recommends adenotonsillectomy (T&A) as the first-line treatment for pediatric OSA. However, obese children experience...
Wed Oct 07, 2020 13:06
Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasion. Endocr Relat Cancer. 2020 Nov;27(11):601-614 Authors: Lee K, Lee SH, Kim W, Lee J, Park JG, Kim JS, Kim JT, Kang YE, Shong M, Lee HJ, Kim JM, Kim WG, Koo BS, Kim KS, Min JK Abstract Anaplastic thyroid cancer (ATC) is a rapidly growing, highly metastatic cancer with limited therapeutic alternatives, thus targeted therapies need to be developed. This study...
Wed Oct 07, 2020 13:06
Prognostic Value of Tumor Proportion Score in Salivary Gland Carcinoma. Laryngoscope. 2020 Oct 06;: Authors: Sato F, Ono T, Kawahara A, Matsuo K, Kondo R, Sato K, Akiba J, Kawaguchi T, Kakuma T, Chitose SI, Umeno H, Yano H Abstract OBJECTIVE: Limited information is available regarding the role of programmed death ligand 1 (PD-L1) expression and CD8+ tumor-infiltrating lymphocyte (TIL) density in the tumor immune microenvironment (TIM)...
Wed Oct 07, 2020 13:06
Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps. Allergy. 2020 Oct 06;: Authors: Wang ZZ, Song J, Wang H, Li JX, Xiao Q, Yu Z, Wang ZC, Liu JX, Pan L, Yao Y, Chen CL, Lu X, Liu C, Gao P, Liu Z Abstract BACKGROUND: Although the importance of ectopic lymphoid tissues (eLTs) in the pathophysiology of nasal polyps (NPs) is increasingly appreciated, the mechanisms underlying their formation remain unclear....
Wed Oct 07, 2020 13:06
Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults. Hum Brain Mapp. 2020 Oct 06;: Authors: Sun Z, Seo JW, Park HJ, Lee JY, Kwak MY, Kim Y, Lee JY, Park JW, Kang WS, Ahn JH, Chung JW, Kim H Abstract Long-term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients...
Wed Oct 07, 2020 13:06
New insights into the activities and toxicities of the old anti-cancer drug doxorubicin. FEBS J. 2020 Oct 06;: Authors: van der Zanden SY, Qiao X, Neefjes J Abstract The anthracycline drug doxorubicin is among the most used-and useful-chemotherapeutics. While doxorubicin is highly effective in the treatment of various hematopoietic malignancies and solid tumours, its application is limited by severe adverse effects, including irreversible...
Wed Oct 07, 2020 13:06
Current State of Combination of Locoregional Therapies with Immune Checkpoint Inhibition. J Vasc Interv Radiol. 2020 Oct 02;: Authors: Restrepo CR, Field DH, Kim AY Abstract Advances in immunotherapy have changed the landscape of oncology over the past decade. Still, most patients with solid organ tumors do not derive a durable benefit from immunotherapies. How these tumors evade treatment has not been fully elucidated, but several studies...
Wed Oct 07, 2020 13:07
How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis. BMJ Open. 2020 Oct 05;10(10):e044566 Authors: Cunniffe NG, Gunter SJ, Brown M, Burge SW, Coyle C, De Soyza A, Dymond T, Esmail H, Francis DP, Galloway J, Galloway JB, Gkrania-Klotsas E, Greenaway J, Katritsis G, Kanagaratnam P, Knolle MD, Leonard K, McIntyre ZC, Prudon B, Rampling T, Torok ME, Warne B, Yates M, Matheson NJ, Su L, Villar...
Wed Oct 07, 2020 13:07
Campylobacteriosis following immunosuppression for immune checkpoint inhibitor-related toxicity. J Immunother Cancer. 2020 Oct;8(2): Authors: Lee KA, Shaw H, Bataille V, Nathan P Abstract Five patients receiving checkpoint inhibitor immunotherapy (CPI) under our care across two cancer centers over a 12-month period have subsequently developed campylobacterosis. All had received immune-suppressive treatment for CPI-related colitis in the weeks...
Wed Oct 07, 2020 13:07
Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options? Clin Pharmacol Ther. 2020 Oct 05;: Authors: Knikman JE, Gelderblom H, Beijnen JH, Cats A, Guchelaar HJ, Henricks LM Abstract Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although most often well tolerated, severe toxicity is encountered in approximately 20-30% of the...
Wed Oct 07, 2020 13:07
The endoscopic diagnosis of mucosal healing and deep remission in inflammatory bowel disease. Dig Endosc. 2020 Oct 05;: Authors: Moriichi K, Fujiya M, Okumura T Abstract The therapeutic goal in inflammatory bowel disease (IBD) patients has shifted from controlling the clinical activity alone to managing other associated problems. The concept of mucosal healing (MH) and deep remission (DR) are advocated and regarded as new therapeutic goals...
Wed Oct 07, 2020 13:07
Comparative effectiveness study of chemotherapy in follicular lymphoma patients in the rituximab era: a Japanese claims database study. Future Oncol. 2020 Oct 06;: Authors: Tsutsué S, Tobinai K, Yi J, Crawford B Abstract Aim: To evaluate comparative effectiveness of rituximub (R)-based versus non-R-based therapies for follicular lymphoma patients in Japan, where limited studies have been reported. Materials & methods: Patients who received...
Wed Oct 07, 2020 13:07
Integrating the melanoma 31-gene expression profile test to surgical oncology practice within national guideline and staging recommendations. Future Oncol. 2020 Oct 06;: Authors: Hyams DM, Covington KR, Johnson CE, Plasseraud KM, Cook RW Abstract Aim: Define changes in clinical management resulting from use of the prognostic 31-gene expression profile (31-GEP) test for cutaneous melanoma in a surgical oncology practice. Patients & methods:...
Wed Oct 07, 2020 13:07
Recent developments and ongoing trials in transplant oncology. Liver Int. 2020 Oct;40(10):2326-2344 Authors: Moeckli B, Ivanics T, Claasen M, Toso C, Sapisochin G Abstract Over the past two decades since the introduction of the Milan criteria, the field of transplant oncology has undergone a rapid development with a rising proportion of liver transplantations being performed for oncological indications. For many patients with liver tumours,...
Wed Oct 07, 2020 13:07
Effect of comorbidities/comedications on sunitinib outcomes for metastatic renal cell carcinoma: the STAR-TOR registry. Future Oncol. 2020 Oct 06;: Authors: Boegemann M, Schlack K, Rink M, Bernhardt S, Moran M, Hubbe M, Bergmann L, Schmid M, Strauss A Abstract Aim: Examine the effects of baseline hypertension (HTN) and statin or proton pump inhibitor (PPI) use on sunitinib treatment outcomes in STAR-TOR, a real-world registry. Materials &...
Wed Oct 07, 2020 13:07
Rehabilitation and palliative care for socioeconomically disadvantaged patients with advanced cancer: a scoping review. Acta Oncol. 2020 Oct 06;:1-12 Authors: Sampedro Pilegaard M, Knold Rossau H, Lejsgaard E, Kjer Møller JJ, Jarlbaek L, Dalton SO, la Cour K Abstract BACKGROUND: Rehabilitation and palliative care may play an important role in addressing the problems and needs perceived by socioeconomically disadvantaged patients with advanced...
Wed Oct 07, 2020 13:07
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. Biol Chem. 2020 Oct 01;: Authors: Schult P, Paeschke K Abstract DHX36 is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of DHX36 in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways...
Wed Oct 07, 2020 13:07
Clinical verification of 18F-DCFPyL PET-detected lesions in patients with biochemically recurrent prostate cancer. PLoS One. 2020;15(10):e0239414 Authors: Meijer D, Jansen BHE, Wondergem M, Bodar YJL, Srbljin S, Vellekoop AE, Keizer B, van der Zant FM, Hoekstra OS, Nieuwenhuijzen JA, Dahele M, Vis AN, Oprea-Lager DE Abstract PURPOSE: Radiolabeled Prostate-Specific Membrane Antigen (PSMA) PET/CT is the current standard-of-care for lesion detection...
Wed Oct 07, 2020 13:07
Desmoid tumors: To treat or not to treat, that is the question. Cancer. 2020 Oct 06;: Authors: Kasper B, Raut CP, Gronchi A Abstract Desmoid tumors (DTs) are a rare disease of intermediate malignancy characterized histologically by a locally aggressive, monoclonal, fibroblastic proliferation and clinically by a variable and often unpredictable course. For decades, surgical resection has been the standard initial treatment approach; however,...
Wed Oct 07, 2020 13:07
Evaluation of medical practices in oncology in the context of the COVID-19 pandemic in France: Physicians' point of view: the PRATICOVID study. Cancer Med. 2020 Oct 06;: Authors: Helissey C, Cessot A, Boudin L, Romeo E, Prieux C, Ghebriou D, Schernberg A, Grellier N, Joly C, Bauduceau O, Thibault C, Mamou E, Raynal G, Serey Eiffel S, Le Floch H, Ricard D, Brureau L Abstract The cancer population seems to be more susceptible to COVID-19 infection...
Wed Oct 07, 2020 13:07
Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020 Sep 29;98:106459 Authors: How J, Leiva O, Bogue T, Fell GG, Bustoros MW, Connell NT, Connors JM, Ghobrial IM, Kuter DJ, Mullally A, Neuberg D, Zwicker JI, Fogerty AE, Hobbs GS Abstract Pregnancy in essential thrombocythemia (ET) is associated with increased risk of obstetric complications. We retrospectively evaluated risk...
Wed Oct 07, 2020 13:07
A Pilot Study of a Comprehensive Financial Navigation Program in Patients With Cancer and Caregivers. J Natl Compr Canc Netw. 2020 Oct;18(10):1366-1373 Authors: Watabayashi K, Steelquist J, Overstreet KA, Leahy A, Bradshaw E, Gallagher KD, Balch AJ, Lobb R, Lavell L, Linden H, Ramsey SD, Shankaran V Abstract BACKGROUND: Few studies have engaged patients and caregivers in interventions to alleviate financial hardship. We collaborated with Consumer...
Wed Oct 07, 2020 13:07
Highlighting sarcopenia management for promoting surgical outcomes in esophageal cancers: evidence from a prospective cohort study. Int J Surg. 2020 Oct 03;: Authors: Wang PY, Chen XK, Liu Q, Yu YK, Xu L, Liu XB, Zhang RX, Wang ZF, Li Y Abstract BACKGROUND: Studies have provided controversial and limited knowledge regarding the impact of sarcopenia on surgical outcomes in esophageal cancers due to retrospective study designs and single...
Wed Oct 07, 2020 13:08
A Letter to the Editor on "Root of helix inter tragus notch incision (RHITNI) for temporomandibular open surgery". Int J Surg. 2020 Oct 03;: Authors: Ângelo DF PMID: 33022415 [PubMed - as supplied by publisher]
Wed Oct 07, 2020 13:08
Related Articles The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma. Front Immunol. 2019;10:2457 Authors: Liao P, Wang H, Tang YL, Tang YJ, Liang XH Abstract Head and neck squamous cell carcinomas (HNSCCs) are closely linked with immunosuppression, accompanied by complex immune cell functional activities. The abnormal competition between costimulatory and coinhibitory signal molecules plays...
Wed Oct 07, 2020 13:14
c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair. Int J Mol Sci. 2020 Oct 01;21(19): Authors: Deville SS, Delgadillo Silva LF, Vehlow A, Cordes N Abstract The intermediate filament synemin has been previously identified as novel regulator of cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase is...
Wed Oct 07, 2020 13:14
Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasion. Endocr Relat Cancer. 2020 Nov;27(11):601-614 Authors: Lee K, Lee SH, Kim W, Lee J, Park JG, Kim JS, Kim JT, Kang YE, Shong M, Lee HJ, Kim JM, Kim WG, Koo BS, Kim KS, Min JK Abstract Anaplastic thyroid cancer (ATC) is a rapidly growing, highly metastatic cancer with limited therapeutic alternatives, thus targeted therapies need to be developed. This study aimed...
Wed Oct 07, 2020 13:14
Efficacy and toxicity of re-irradiation spine stereotactic body radiotherapy with respect to irradiation dose history. Jpn J Clin Oncol. 2020 Oct 06;: Authors: Ito K, Ogawa H, Nakajima Y Abstract OBJECTIVE: We aimed to clarify the outcomes of re-irradiation stereotactic body radiotherapy for spinal metastases with a uniform dose fractionation schedule at our institution. METHODS: Data of patients treated with re-irradiation stereotactic...
Wed Oct 07, 2020 13:14
Five-year follow-up results from phase II studies of nivolumab in Japanese patients with previously treated advanced non-small cell lung cancer: pooled analysis of the ONO-4538-05 and ONO-4538-06 studies. Jpn J Clin Oncol. 2020 Oct 06;: Authors: Saka H, Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Horinouchi H, Takenoyama M, Katakami N, Tanaka H, Takeda K, Satouchi M, Isobe H, Maemondo M, Goto K, Hirashima T, Minato K, Yada N, Tamura...
Wed Oct 07, 2020 13:14
[Auditory processing in children and adolescents with cleft palate]. Laryngorhinootologie. 2020 Oct 06;: Authors: Hofer-Martini S, Hofer M, Hemprich A, Berger T, Fuchs M, Meuret S Abstract BACKGROUND: Patients with cleft palate often suffer from recurrent otitis media chronica with effusion during infancy. The consecutive binaural conductive hearing loss is seen as a risk factor for developing auditory processing disease. Since there are just...
Wed Oct 07, 2020 13:14
Peritoneal Dialysis in a Patient with Acute Kidney Injury, Thrombocytopenia, Urosepsis, and Liver Cirrhosis: A Case Report. Am J Case Rep. 2020 Oct 06;21:e926226 Authors: Cieszyński K, Grzegorzewska AE Abstract BACKGROUND We present the possibility of successful peritoneal dialysis (PD) treatment in acute kidney injury (AKI) patients with multiple comorbidities. CASE REPORT A 60-year-old woman with chronic kidney disease (CKD, stage G3b), liver...
Wed Oct 07, 2020 13:26
Successful Treatment of a Patient with Chronic Myelogenous Leukemia with Concurrent Janus Kinase 2 (JAK2) R795S Mutation and Breakpoint Cluster Region-ABL1 (BCR-ABL1) Fusion: A Case Report and Literature Review. Am J Case Rep. 2020 Oct 06;21:e925151 Authors: Yue Y, Wei W, Guo Y, Wang F, Dong W, Liu Y, Lin Y, Cao Y, Gu W Abstract BACKGROUND Although the V617F mutation in the Janus kinase 2 (JAK2) gene and the breakpoint cluster region-abl1 (BCR-ABL1)...
Wed Oct 07, 2020 13:26
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