Publication date: Available online 7 October 2020Source: Brain Research BulletinAuthor(s): Priscila Medeiros, Mariana Oliveira-Silva, Sylmara Esther Negrini-Ferrari, Ana Carolina Medeiros, Daoud Hibraim Elias-Filho, Norberto Cysne Coimbra, Renato Leonardo de Freitas
Wed Oct 07, 2020 18:11
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Jingyang Zhou
Wed Oct 07, 2020 18:22
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Moezedin Javad Rafiee, Faranak Babaki Fard, Matthias G. Friedrich
Wed Oct 07, 2020 18:22
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Abdorreza Naser Moghadasi
Wed Oct 07, 2020 18:22
Publication date: Available online 6 October 2020Source: CortexAuthor(s): Alfredo Spagna, Tingting Wu, Kevin Kim, Jin Fan
Wed Oct 07, 2020 18:28
Publication date: Available online 6 October 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Victor Lopez-Rivera, Antonio Dono, Rania Abdelkhaleq, Sunil A. Sheth, Peng R. Chen, Ankush Chandra, Leomar Y. Ballester, Yoshua Esquenazi
Wed Oct 07, 2020 18:29
Publication date: Available online 6 October 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Collin J. Larkin, Zachary A. Abecassis, Ketan Yerneni, Dominic A. Nistal, Constantine L. Karras, H. Greg Frankel, Amit Ayer, Nader S. Dahdaleh
Wed Oct 07, 2020 18:29
Publication date: Available online 7 October 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Guoliang Chen, Mengxian Jia, Raymond Kobina Connel, Yadong Sheng, Chaowei Lin, Kelun Huang, Jinwei Ying, Honglin Teng
Wed Oct 07, 2020 18:29
A Systematic Review and Meta-Analysis: The Effect of Active Cancer Treatment on Severity of COVID-19
Publication date: Available online 6 October 2020Source: European Journal of CancerAuthor(s): Emre Yekedüz, Güngör Utkan, Yüksel Ürün
Wed Oct 07, 2020 18:48
Publication date: Available online 6 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Maynara Lemos Abreu Silva, Wagner Henriques de Castro, Felipe Eduardo Baires Campos
Wed Oct 07, 2020 19:04
Publication date: Available online 7 October 2020Source: Behavioural Brain ResearchAuthor(s): Fatma Ben Waer, Rabeb Laatar, Ghada Jouira, Selim Srihi, Haithem Rebai, Sonia Sahli
Wed Oct 07, 2020 19:05
Publication date: Available online 6 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jianghui Meng, Jiafu Wang
Wed Oct 07, 2020 19:18
Publication date: Available online 7 October 2020Source: Computer Speech & LanguageAuthor(s): Roldano Cattoni, Mattia Antonino Di Gangi, Luisa Bentivogli, Matteo Negri, Marco Turchi
Wed Oct 07, 2020 19:20
Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy
This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to...
Wed Oct 07, 2020 03:00
Background: Endobronchial ultrasound elastography that provides information on tissue stiffness may help distinguish malignant from benign mediastinal and hilar lymph nodes. Objectives: In this prospective trial, we assessed the diagnostic value of elastographic images and the interobserver agreement in its evaluation. Method: Elastographic images from 77 lymph nodes in 65 patients were reviewed by 3 pneumologists. The elastographic image was classified based on the predominant colour: predominantly...
Wed Oct 07, 2020 11:35
Publication date: Available online 6 October 2020Source: World NeurosurgeryAuthor(s): Fadi Al Saiegh, Ritam Ghosh, Anthony Stefanelli, Omaditya Khanna, Ellina Hattar-Medina, Michelle Hoffman, Karim Hafazalla, Victor Sabourin, Christopher Farrell, Stavropoula Tjoumakaris, Pascal Jabbour, Ashwini D. Sharan, Robert H. Rosenwasser
Wed Oct 07, 2020 19:36
Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Jeyaseelan Nadarajah, Ajay Garg, Sandeep Bohara, Kanwaljeet Garg, Leve Joseph Devaranjan Sebastian, Vaishali Suri, Sameer Bakhshi, Manmohan Singh
Wed Oct 07, 2020 19:35
Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Elric Brahm Malelak, Christopher Lauren, Donny Argie, Tri Nugraheni
Wed Oct 07, 2020 19:35
Tissue Engineering Part A, Ahead of Print.
Fri Sep 18, 2020 10:00
Publication date: Available online 6 October 2020Source: Clinical ImagingAuthor(s): Vilert A. Loving
Wed Oct 07, 2020 19:55
Publication date: Available online 7 October 2020Source: Clinical ImagingAuthor(s): Gabin Yun, Tao Huang, David O'Dwyer, Aamer Chugtai, Prachi Agarwal
Wed Oct 07, 2020 19:55
Publication date: Available online 7 October 2020Source: Clinical ImagingAuthor(s): Paige McMahon, Melissa Reichman, Katerina Dodelzon
Wed Oct 07, 2020 19:55
Publication date: Available online 7 October 2020Source: Clinical ImagingAuthor(s): Giovanni Foti, Massimo Guerriero, Niccolò Faccioli, Alessandro Fighera, Luigi Romano, Claudio Zorzi, Giovanni Carbognin
Wed Oct 07, 2020 19:55
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Shingo Kihira, Javin Schefflein, Puneet Pawha, Brian Rigney, Bradley N. Delman, Dwight Xuan, Johanna Fifi, Amish H. Doshi, Puneet Belani
Wed Oct 07, 2020 19:55
Publication date: Available online 6 October 2020Source: Archives of Oral BiologyAuthor(s): Ahmed Algohar, Ali Alqerban
Wed Oct 07, 2020 20:03
Publication date: Available online 6 October 2020Source: Archives of Oral BiologyAuthor(s): Yi Wang, Antonia T.W. Lam
Wed Oct 07, 2020 20:03
Publication date: Available online 6 October 2020Source: Archives of Oral BiologyAuthor(s): Beatriz Martines de Souza, Larissa Rodrigues Pereira Santi, Samira Helena João-Souza, Thiago Saads Carvalho, Ana Carolina Magalhães
Wed Oct 07, 2020 20:03
Publication date: Available online 6 October 2020Source: Archives of Oral BiologyAuthor(s): Céline Stutz, Fareeha Batool, Catherine Petit, Marion Strub, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel, Olivier Huck
Wed Oct 07, 2020 20:03
Publication date: Available online 6 October 2020Source: Archives of Oral BiologyAuthor(s): Yi Wang, Antonia T.W. Lam
Wed Oct 07, 2020 20:03
Publication date: Available online 7 October 2020Source: Archives of Oral BiologyAuthor(s): Vanessa Peret Jacob, Luana Isabel Paião, Ana Carolina Gomes da Silva, Mychelle Keiko Watanabe Magario, Taís Yukari Kaneko, Christine Men Martins, Douglas Roberto Monteiro, Graziela Garrido Mori
Wed Oct 07, 2020 20:03
Publication date: Available online 7 October 2020Source: Archives of Oral BiologyAuthor(s): Tyresia White, Yelena Alimova, Vanessa Tubero Euzebio Alves, Pinar Emecen-Huja, Mohanad Al-Sabbagh, Alejandro Villasante, Jeffrey L. Ebersole, Octavio A. Gonzalez
Wed Oct 07, 2020 20:03
Publication date: Available online 7 October 2020Source: Archives of Oral BiologyAuthor(s): Marcelo Queiroz D’Ângelo, Celso Martins Queiroz-Junior, Kátia Lucy de Melo Maltos, Anderson José Ferreira, Cinthia Mara da Fonseca Pacheco, Rodrigo Villamarim Soares
Wed Oct 07, 2020 20:03
Publication date: Available online 7 October 2020Source: Archives of Oral BiologyAuthor(s): Zongyun Fu, Xusheng Wang, Bin Li, Yanchi Tang
Wed Oct 07, 2020 20:03
Patients undergoing superficial parotidectomy for benign parotid lesions are at risk of postoperative complications, most notably cosmetic complications such as facial paralysis and contour defects, and functi...
Tue Oct 06, 2020 03:00
Within Neurotology, special draping systems have been devised for mastoid surgery recognizing that drilling of middle ear mucosa is an aerosol generating medical procedure (AGMP) which can place surgical teams...
Tue Oct 06, 2020 03:00
Publication date: Available online 7 October 2020Source: Sleep MedicineAuthor(s): Børge Sivertsen, Allison G. Harvey, Michael Gradisar, Ståle Pallesen, Mari Hysing
Wed Oct 07, 2020 20:22
AbstractA 77-year-old woman with a solitary existence was referred to our hospital for the treatment of pancreatic tumors. Computed tomography revealed an 18-mm mass in the pancreatic head that had invaded the right side of the superior mesenteric vein (SMV) and a 32-mm mass in the pancreatic tail. We performed middle segment-preserving pancreatectomy (MSPP) with SMV resection and reconstruction. The TNM classifications were T2, N1, M0, stage IIB in the pancreatic head, and T2, N0, M0, stage IB in...
Wed Oct 07, 2020 03:00
AbstractA jejunal gastrointestinal stromal tumour (GIST) is a rare neoplasm of the gastrointestinal tract. Massive bleeding due to a jejunal GIST is a diagnostic challenge and could present as a life-threatening situation needing urgent intervention. A 54-year-old woman presented with episodes of melaena and haematochezia for the previous 3 days. An oesophagoduodenoscopy was inconclusive. A contrast computed tomography (CT) scan showed a well-defined extraluminal mass in the proximal jejunum suggestive...
Wed Oct 07, 2020 03:00
AbstractPancreatic duct stones are direct sequelae of chronic pancreatitis (CP) and can occur in ∼50% of patients. Selection of the appropriate treatment method for pancreatic duct stones depends on location, size and number of stones. We present a patient with upper abdominal pain and weight loss for the previous 3 months. Diagnostic workup detected a chronic inflammation of the pancreas with stone in the main pancreatic duct and a nodular lesion in the head of the pancreas. Endoscopic retrograde...
Wed Oct 07, 2020 03:00
Abstract Objectives To investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva. Materials and Methods Clasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent),...
Wed Oct 07, 2020 03:00
Abstract Objectives To evaluate the selenium (Se) behavior when used as an endodontic dressing in teeth with pulp necrosis. Additionally, its effects was also compared with the calcium hydroxide (C.H.), which is used globally as a root canal dressing, and the combination of the C.H. with Se (C.H. + Se). Materials and methods The sample consisted of 60 patients...
Wed Oct 07, 2020 03:00
Thyroid, Ahead of Print.
Wed Oct 07, 2020 10:00
Thyroid, Ahead of Print.
Wed Oct 07, 2020 10:00
Surgical Infections, Ahead of Print.
Wed Oct 07, 2020 10:00
A series of methods to determine the potential DNRA rate based on 14NH4+/15NH4+ analyses is provided in detail. NH4+ is converted into N2O via several steps and analyzed using quadrupole gas chromatography–mass spectrometry.
Wed Oct 07, 2020 19:36
The goal of this work is to develop a method to reproducibly isolate cardiomyocytes from the adult heart and measure DNA content and nucleation.
Wed Oct 07, 2020 20:37
Publication date: Available online 7 October 2020Source: Journal of Neuroscience MethodsAuthor(s): Benjamin W. Metcalfe, Alan J. Hunter, Jonathan E. Graham-Harper-Cater, John T. Taylor
Wed Oct 07, 2020 20:49
Abstract Background Despite the integral role of cephalometric analysis in orthodontics, there have been limitations regarding the reliability, accuracy, etc. of cephalometric landmarks tracing. Attempts on developing automatic plotting systems have continuously been made but they are insufficient for clinical applications due to low reliability of specific landmarks. In this study, we aimed to develop a novel framework for locating...
Wed Oct 07, 2020 03:00
Abstract Background Fully adjustable articulators and pantographs record and reproduce individual mandibular movements. Although these instruments are accurate, they are operator-dependant and time-consuming. Pantographic recording is affected by inter and intra operator variability in the individuation of clinical reference points and afterwards in reading pantographic recording themselves. Finally only border movements can be...
Wed Oct 07, 2020 03:00
Abstract Background General dentists are often the first healthcare professionals to see patients with orofacial pain (OFP). OFP conditions associated with the temporomandibular joint are often confused with dentoalveolar disorders, which leads to mismanagement. The objective of this study was to evaluate the level of knowledge of temporomandibular disorders (TMD) among newly graduated dentists compared to OFP specialists in Saudi...
Wed Oct 07, 2020 03:00
Abstract Background The aim of this study was to analyze the root and canal morphology of the maxillary permanent first molars in an Emirati population using cone-beam computed tomography (CBCT). Methods Two hundred and sixty-one CBCT scans were acquired. The data were extracted and anonymized to remove all patient identifiers. Two observers...
Wed Oct 07, 2020 03:00
Abstract Background The insertion of dental implants in the atrophic posterior maxilla can be a challenge. One option is to modify the residual native bone in preparation for proper, prosthetically-driven implant placement. The procedure presented in this study is called Navigated Antral Bone Expansion (N.A.B.E). This procedure employs the use of a navigation system to plan and guide the initial pilot drilling, bone expansion,...
Wed Oct 07, 2020 03:00
Abstract AMOTL1 belongs to the Motin family of proteins that are involved in organogenesis and tumorigenesis through regulation of cellular migration, tube formation, and angiogenesis. While involvement of all AMOTs in development or suppression of cancers is relatively well described, little is known about the congenital phenotype of pathogenic variants in these genes in humans. Recently, a heterozygous variant in AMOTL1 was published in association with orofacial clefts and cardiac abnormalities...
Wed Oct 07, 2020 14:38
Abstract Congenital hiatal hernia (HH) is a rare congenital defect and is often described on a sporadic basis, but familial cases have also been reported. The mechanism of development is not well understood, and to our knowledge no specific genetic factors have been implicated to date. We report on seven individuals from two families with 9q22 duplication, who have variably associated features including congenital HH in four individuals. One family had an 1.09 Mb 9q22 duplication, and the other...
Wed Oct 07, 2020 14:39
Abstract This objective of this systematic review was to estimate live birth rate and explore prognostic indicators in fetuses with 45,X karyotype and a posterior cystic hygroma (CH). Electronic databases were searched and studies reporting pregnancy outcomes (termination, spontaneous abortion, demise, or live birth) for fetuses with 45,X karyotype and a CH diagnosed on ultrasound were included. For cases of survival, CH characteristics, presence of hydrops fetalis, or concomitant anomalies, delivery...
Wed Oct 07, 2020 14:46
Abstract Purpose Acute stroke patients presenting with a distal internal carotid artery occlusion and patent carotid terminus, allowing for collateral flow via the circle of Willis, may have a more favorable natural history. Therefore, benefit of endovascular treatment (EVT) is less evident. We performed an exploratory analysis of EVT results compared to conservative treatment in patients with ‘carotid-I’ occlusions. ...
Wed Oct 07, 2020 03:00
Abstract Purpose The vessel wall MR imaging (VWI) literature was systematically reviewed to assess the criteria and measurement methods of VWI-related imaging endpoints for symptomatic intracranial plaque in patients with ischemic events. Methods PubMed, Scopus, Web of Science, EMBASE, and Cochrane databases were searched up to October 2019. Two independent...
Wed Oct 07, 2020 03:00
Publication date: Available online 7 October 2020Source: American Journal of Infection ControlAuthor(s): Margarita L. Martinez-Fierro, Jorge Ríos-Jasso, Idalia Garza-Veloz, Lucia Reyes-Veyna, Rosa Maria Cerda-Luna, Iliana Duque-Jara, Maribel Galvan-Jimenez, Leticia A Ramirez-Hernandez, Andres Morales-Esquivel, Yolanda Ortiz-Castro, Jose R Gutierrez-Camacho, José J Valdes-Aguayo, Jose R Vargas-Rodriguez
Wed Oct 07, 2020 22:46
Background and Objectives Keloids are described as benign dermal fibroproliferative lesions, and vascularization may play a significant role in their pathogenesis. In this study, laser speckle contrast imaging (LSCI) was used to assess perfusion within keloids and surrounding skin, and perfusion of keloids at different stages was compared. Study Design/Materials and Methods A total of 59 patients with 110 untreated keloids on the anterior chest were enrolled in this study. Different keloid...
Wed Oct 07, 2020 22:51
Background and Objectives To investigate the safety and efficacy of a dual‐wavelength 1064/532‐nm picosecond‐domain laser for tattoo removal in Vietnamese patients. Study Design/Materials and Methods This prospective clinical study enrolled 30 subjects with 52 decorative tattoos treated with up to six treatments of laser removal at intervals of 6–8 weeks. Safety and efficacy were assessed at each treatment session and at 4 weeks after the final session. A “good” response was defined as at...
Wed Oct 07, 2020 22:52
A statistical analysis of that vast database is helping scientists better understand the evolution of these cold-blooded vertebrates by contradicting a widely held theory that major transitions in evolution always happened in big, quick (geologically speaking) bursts, triggered by major environmental shifts.
Tue Oct 06, 2020 23:57
A newly discovered species of toothless, two-fingered dinosaur has shed light on how a group of parrot-like animals thrived more than 68 million years ago.
Wed Oct 07, 2020 05:02
Working with fish, birds and mice, researchers report new evidence that some animals' natural capacity to regrow neurons is not missing, but is instead inactivated in mammals.
Wed Oct 07, 2020 19:31
The use of robotics in otolaryngology has dramatically accelerated over the last one and a half decades. In 2020, robotic surgery has left a mark in many subspecialties within the field of otolaryngology–head and neck surgery. In some subspecialties, such as in head and neck surgical oncology, there is over a decade of experience with robotics; as a result, it has broad acceptance and a large body of evidence, although areas of controversy certainly exist. In other subspecialties, robotic surgery...
Wed Oct 07, 2020 03:00
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions of lncRNAs in colorectal cancer (CRC) have not been systemat...
Tue Oct 06, 2020 03:00
Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel sig...
Wed Oct 07, 2020 03:00
Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the...
Wed Oct 07, 2020 03:00
Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d...
Wed Oct 07, 2020 03:00
High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le...
Wed Oct 07, 2020 03:00
Publication date: Available online 7 October 2020Source: Radiotherapy and OncologyAuthor(s): Di Yan, Shupeng Chen, Daniel J Krauss, Rohan Deraniyagala, Peter Chen, Hong Ye, George Wilson
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Publication date: Available online 7 October 2020Source: Radiotherapy and OncologyAuthor(s): Rebecca G. Levin-Epstein, Naomi Y. Jiang, Xiaoyan Wang, Shrinivasa K. Upadhyaya, Sean P. Collins, Simeng Suy, Nima Aghdam, Constantine Mantz, Alan J. Katz, Leszek Miszczyk, Aleksandra Napieralska, Agnieszka Namysl-Kaletka, Nicholas Prionas, Hilary Bagshaw, Mark K. Buyyounouski, Minsong Cao, Nzhde Agazaryan, Audrey Dang, Ye Yuan, Patrick A. Kupelian
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Publication date: Available online 7 October 2020Source: Radiotherapy and OncologyAuthor(s): Mateusz C. Florkow, Filipa Guerreiro, Frank Zijlstra, Enrica Seravalli, Geert O. Janssens, John H. Maduro, Antje C. Knopf, René M. Castelein, Marijn van Stralen, Bas W. Raaymakers, Peter R. Seevinck
00:26
Abstract Purpose To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Methods Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (n = 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent...
Wed Oct 07, 2020 03:00
A novel coronavirus named severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China, in December 2019. The virus, known as COVID-19, is recognized as a potentially life-threatening di...
Tue Oct 06, 2020 03:00
Determining the infectiousness of patients with coronavirus disease 2019 is crucial for patient management. Medical staff usually refer to the results of reverse transcription polymerase chain reaction tests i...
Wed Oct 07, 2020 03:00
Pyopneumothorax secondary to Streptococcus constellatus infection is a clinically rare event, and few cases have been reported.
Wed Oct 07, 2020 03:00
To assess, through both objective and subjective methods, the complaints of dysphonia among adults with rheumatoid arthritis (RA). The secondary purpose of the study is to determine whether complaints of dysphonia are related to depression and disease activity.
Wed Oct 07, 2020 03:00
Abstract Deep neck space infections are really challenging to the otothinolaryngologist, intensivist and to the anesthetist for managing at a tertiary care center. Proper handling of such cases is needed in time to save the life of such patient. We reported a case 65 year female patient present with sudden onset of huge submental and submandibular swelling admitted in ICU with difficult intubation.
Wed Oct 07, 2020 03:00
Abstract The nasal type of extranodal natural killer (NK)/T-cell lymphoma (ENKL) is an aggressive form of non-Hodgkin’s lymphoma. Although ENKL is most commonly seen in the midline of the nose, face and Waldeyer's ring, it can also occur in the skin, gastrointestinal tract, soft tissues and other parts of the body. Severe ENKL cases are accompanied by hemophagocytosis, with clinical manifestations such as high fever, hepatosplenomegaly, and decreased blood cell count. ENKL at...
Wed Oct 07, 2020 03:00
Abstract Post treatment voice quality is an important consideration in choosing the management option for laryngeal cancer. We assessed voice quality after radiotherapy in patients of early squamous cell carcinoma of glottis comprehensively using Videolaryngostroboscopy (VLS), Grade, Roughness, Breathiness, Asthenia and Strain (GRBAS) scores and Voice Handicap Index (VHI)-10. Fifty four consenting patients of early squamous cell carcinoma of glottis (Tis, T1 and T2) awaiting definitive...
Wed Oct 07, 2020 03:00
Patient prioritization is a strategy used to manage access to healthcare services. Patient prioritization tools (PPT) contribute to supporting the prioritization decision process, and to its transparency and f...
Tue Oct 06, 2020 03:00
Asthma is one of the most common chronic respiratory conditions in the world and is increasing in prevalence, particularly in Africa and other low-income countries. The disproportionately high numbers of prema...
Wed Oct 07, 2020 03:00
Lumbar spinal stenosis (LSS) and knee and hip osteoarthritis (OA) are prevalent conditions in the aging population and published literature suggests they share many symptoms and often are present at the same t...
Wed Oct 07, 2020 03:00
Cardiovascular disease (CVD) is the leading cause of death in women, responsible for approximately a third of all female deaths. Pregnancy complications are known to be associated with a greater risk of incide...
Wed Oct 07, 2020 03:00
Mental health (MH) problems are among the most important causes of morbidity and mortality for children and youth. Problems of lack of equity in child and youth MH services (CYMHS)—including, but not limited t...
Wed Oct 07, 2020 03:00
Dextro-transposition of the great arteries (d-TGA) is the most frequent cyanotic congenital heart pathology in neonates. Surgical correction of this condition is possible using the arterial switch operation (ASO)...
Wed Oct 07, 2020 03:00
Abstract Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiology of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative dimethyl itaconate on inflammation in sepsis. We established...
Wed Oct 07, 2020 03:00
Abstract The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) as a functional “receptor” and then enters into host cells to replicate and damage host cells and organs. ACE2 plays a pivotal role in the inflammation, and its downregulation may aggravate COVID-19...
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Chronic hand and wrist impairment are frequently present following stroke and severely limit independence in everyday life. The wrist orientates and stabilizes the hand before and during grasping, and is there...
Wed Oct 07, 2020 03:00
Objectives: The treatment of nonmetastatic HER2-positive breast cancer with residual invasive disease using concurrent Trastuzumab emtansine (T-DM1) and radiotherapy appears to be an effective option. Our aim was to evaluate the acute side effects of this treatment regime. Methods: Fourteen patients were treated between March 2019 and April 2020 concurrent T-DM1 and radiotherapy. Left ventricular ejection fraction was assessed at baseline, before and after radiotherapy. All toxicities...
Tue Oct 06, 2020 03:00
Mesothelioma is a rare, aggressive malignancy with poor outcome, and has limited treatment options. The aim of this study was to perform a comprehensive analysis of programmed death ligand 1 (PD‐L1) and B7 homolog 3 (B7‐H3) expression in mesothelioma. We investigated the protein expression of PD‐L1 and B7‐H3 and their potential correlation with histological subtype, which might help to develop new therapies targeting these immune checkpoint molecules. Expression analysis of PD‐L1 and B7‐H3 was performed...
Wed Oct 07, 2020 22:54
Abstract Gait stability and secondary task performance are affected by the need to share attention when dual-tasking. Further decrements may result from the need to switch attention between multiple secondary tasks. The aim of the current study was to determine the effects of attention switching upon gait stability and task performance in healthy younger and older adults. Ten healthy younger and ten healthy older adults walked on a treadmill at their preferred speed during three...
Tue Oct 06, 2020 03:00
Abstract Early-life stress is correlated with the development of anxiety-related behavior in adolescence, but underlying mechanisms remain poorly known. The α1A-adrenergic receptor (AR) is linked to mood regulation and its function is assumed to be regulated by β-arrestins (βArrs) via desensitization and downregulation. Here, we investigated correlation between changes in α1A-AR and βArr2 levels in the prefrontal cortex (PFC) and hippocampus of adolescent and adult male rats subjected...
Tue Oct 06, 2020 03:00
Abstract The purpose of this study was to determine if the implementation of a strict validation procedure, designed to limit the inclusion of inaccuracies from the decomposition of surface electromyographic (sEMG) signals, affects population-based motor unit (MU) analyses. Four sEMG signals were obtained from the vastus lateralis of 59 participants during isometric contractions at different relative intensities [30%, 70%, and 100% of maximal voluntary contraction (MVC)], and...
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