Abstract As part of a larger study on the effects of fatigue on various attentional and behavioural measures, we had participants complete a modified version of Luna et al.’s (J Neurosci Methods 306:77–87, Luna et al., J Neurosci Methods 306:77–87, 2018) ANTI-Vea task (mANTI-Vea) at the beginning and end (pre/post) of each of two 8-h testing sessions. Between these administrations of the mANTI-Vea our participants spent ~ 6 h performing an intervening task. Our intent in this...
03:04
Abstract Empirical evidence has demonstrated functional (mostly right-biased) brain asymmetry for emotion perception, whereas recent studies indicate that acute stress may modulate left and/or right hemisphere activation. However, it is still unknown whether emotion perception can be influenced by stress-induced hemispheric activation since behavioral studies report inconsistent or even contradictory results. We sought to reevaluate this gap. Eighty-eight healthy Caucasian university...
03:04
Abstract Paired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is attenuated in older and less active individuals. Although a single bout of exercise enhances PAS-induced plasticity in young, physically inactive adults, it is not yet known if physical activity interventions affect PAS-induced neuroplasticity in middle-aged inactive individuals. Sixteen inactive middle-aged office...
03:04
Abstract Mental imagery can induce audiovisual integration, but whether it can induce interactions in other modalities remains uncertain. It has been demonstrated that audiomotor interaction can be generated following training, but whether such audiomotor interaction can be induced by auditory imagery training remains unknown. The present study aims at determining whether auditory mental imagery could induce a multimodal association with postural control. We examined static postural...
03:04
Abstract It remains to be investigated whether syntax-related mismatch activity would be evoked in event-related optical signals by syntactic violations that deviate from our language knowledge and expectations. In the current study, we have employed fast optical neuroimaging with a frequency-domain oximeter to examine whether syntactic violations of English bare infinitives in the non-finite complement clause would trigger syntax-related mismatch effects. Recorded sentences...
03:04
Abstract Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is ~ 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo and ex-vivo in rats of both sexes. For in-vivo experiments, male, female and ovariectomized rats were separated...
03:04
Abstract Transcranial magnetic stimulation (TMS) produces motor-evoked potentials (MEP) used to infer changes in corticomotor excitability. In humans, neck rotation can probe reticulospinal input on corticomotor output. This study investigated the effect of neck rotation on MEP duration in a proximal and distal upper limb muscle and compared responses between rest and preactivation. Single-pulse TMS to motor cortex was used to evoke MEPs at two stimulus intensities in 18 healthy...
03:04
Abstract It is now accepted that performing a cognitive task impacts postural control (Polskaia and Lajoie 2016; Vuillerme et al. Neurosci Lett 291: 77–80, 2000). However, the reverse impact of posture on cognitive performance is less documented. The present study investigated performance in two cognitive activities (memory and arithmetic) performed in three different postural conditions (sitting, standing, and walking). Overall, our data suggest that the posture adopted during...
03:04
Abstract Subjects’ eye movement behavior related to cognitive effort during gait was measured as subjects walked to perform low and high cognitive load tasks. We found that all pupil diameter measures, fixation durations, and the proportion of blink duration changed significantly during gait as a function of task load. In contrast, the number of fixations, saccade durations and travel time did not change significantly as a function of task load. Findings showed that pupil diameter...
03:04
Abstract Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to test collagen hydrogels loaded with different angiogenic factors to study vessel repair in organotypic brain slice cultures. In the experimental set up I, we made a cut on the organotypic brain slice and tested re-growth of...
03:04
Nasopharyngeal carcinoma (NPC) is rare worldwide but highly prevalent in southern China [1]. Roughly 70% of newly diagnosed cases present with locoregionally advanced NPC (LANPC) [2], whose management remains a challenge as treatment failures occur in nearly 30% of them [3,4]. Induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is currently widely recommended for LANPC due to its high efficacy and acceptable tolerance [5–7].
Wed Oct 07, 2020 03:00
Radiation therapy is a central treatment strategy in the management of cancer and is indicated in more than 50% of all cancer cases [1–4]. The majority of the patients who undergo radiation therapy will do so through external photon radiation therapy utilizing linear accelerators incorporated into a rotating gantry for highly conformal dose deposition within the target [1]. The introduction of these clinical linear accelerators (linacs) into a radiation oncology clinic for cancer treatment will be...
Wed Oct 07, 2020 03:00
Despite the increase in the global incidence of pediatric cancers from 124 to 140.6 per million person-years between 1970 and 2004, the 5-year overall survival rate has improved from 58.1% to 79.6% [1,2]. This incidence varies with age, gender, tumor type, and geographical region. In low- and middle-income countries (LMIC), patients usually present with advanced disease partly due to limited access to early detection facilities and tertiary care centers.
Wed Oct 07, 2020 03:00
Concurrent chemoradiotherapy (CCRT) is the established recommended treatment for patients with locally advanced uterine cervical cancer [1–4]. However, approximately 30% of cervical cancer patients receiving CCRT will develop local recurrence or distant metastasis [5]. Therefore, early identification of patients at higher risk of disease recurrences might be important for optimizing therapeutic strategies. There are several known prognostic factors, including nodal status and tumor size [6,7].
Wed Oct 07, 2020 03:00
Cervical cancer is the second most common cancer in women aged 15 to 44 years worldwide [1,2]. Intensity-modulated radiation therapy (IMRT) has become the preferred radiotherapy method for locally advanced cervical cancer treatment [3]. Accurate delineation of the clinical target volume (CTV) and organ-at-risk (OAR) is one of the essential steps for successful IMRT delivery. Such delineation is conventionally performed by radiotherapy oncologists through laborious manual delineation. The delineation...
Wed Oct 07, 2020 03:00
Medical physics has made considerable contributions to recent advances in radiation oncology. Medical physicists are key players in the clinical and scientific radiation oncology context due to their unique skill sets, flexibility, clinical involvement and intrinsic translational character. The continuing development and widespread adoption of “high-tech” radiotherapy has led to an increased need for medical physics involvement. More recently, our field is rapidly changing towards an era of “precision...
Wed Oct 07, 2020 03:00
Stereotactic body radiotherapy (SBRT) has improved local control and overall survival for both primary and (oligo-)metastatic lung lesions [1–4]. A crucial factor in SBRT is geometrical accuracy, as high conformality and steep dose fall-off in the treatment plan are necessary to fulfill dose constraints on nearby organs at risk and avoid toxicity [5].
Wed Oct 07, 2020 03:00
High dose-rate (HDR) brachytherapy (BT) is commonly used to treat prostate and cervical cancer by irradiating the target volume using dedicated applicators and/or catheters. BT offers sharp dose gradients which may lead to decreased dose to organs at risk compared to external beam radiotherapy.[1,2] Image-guided implant reconstruction has become standard practice, using medical imaging such as CT, MR or ultrasound acquired before treatment planning.[3,4] After reconstructing the applicator and/or...
Wed Oct 07, 2020 03:00
Treatment planning in radiotherapy distinguishes three target volume concepts: GTV, CTV, and PTV. The gross tumor volume (GTV) represents the macroscopic tumor mass, which is typically detectable using biomedical imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and/or positron emission tomography (PET). The clinical target volume (CTV) includes microscopic extensions of the tumor in the surrounding tissue, which are not detectable with current in-vivo imaging...
Wed Oct 07, 2020 03:00
Rolandic epilepsy is one of the most common epileptic syndromes in childhood. We used TMT-based proteomics and bioinformatics analysis to identify the differentially expressed proteins in plasma of children with Rolandic epilepsy. Our aim was to provide a molecular basis for exploring possible mechanisms underlying the pathogenesis of epilepsy. Subjects were divided into two groups (five in each): patients with Rolandic epilepsy as cases and patients with migraine as controls. Total proteins were...
Wed Oct 07, 2020 19:05
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1262-6352Balanced diet and regular physical activity are of key importance to the prevention of the development and progression of non-communicable diseases. In 2050, 50% of the European population is expected to be obese. Cardiovascular diseases, diabetes mellitus, cancer, as well as joint impairments, will further increase. Therefore, programmes are critical to the improvement of the population’s health status in the long run. New ways have to be found...
Wed Oct 07, 2020 02:00
Opinion statement Ongoing advances in our understanding of neuroendocrine tumor (NET) biology, genetics, and immunology, will continue to expand the availability of targeted therapies, thus improving the outcomes of patients. Well-differentiated neuroendocrine tumors (NETs) are grouped into pancreatic and non-pancreatic NETs (includes GI and thoracic NETs) for treatment considerations (Fig. 1). For panNETs, initial therapy is driven by the need of radiographic response, and...
Wed Oct 07, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02148
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08979
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08362
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07485
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08834
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08708
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07657
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07060
Wed Oct 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07781
Wed Oct 07, 2020 07:00
This year has witnessed many sorrows, amidst unthinkable change. Amongst these is the recent passing of Ian T. Jackson, whose Obituary in this Issue is kindly penned by David Soutar, his spiritual heir within the Canniesburn Unit.
Thu Oct 01, 2020 03:00
Ian Jackson was born on Christmas Eve 1934. His formative education was in Scotland, graduating in Medicine from the University of Glasgow in 1959.His postgraduate education continued in Glasgow and included 2 years in Pathology, 3 years in General Surgery and 4 years training in Plastic Surgery. His time in Pathology instilled in him a questioning mind which was to remain throughout his career. He was trained by some of the most respected senior plastic surgeons of that time (Jack Tough, Tom Gibson,...
Thu Oct 01, 2020 03:00
The temporal bone is often affected in basilar skull fractures. Fractures involving the petrous portion are particularly significant, as they may be associated with neurovascular sequelae. Bilateral facial paralysis secondary to bilateral temporal bone fracture is a rare clinical entity, even more so when associated with other cranial nerve damage such as abducens nerve paralysis and hearing impairment. Only 4 similar cases have been reported in the literature to date. In this paper, we describe...
Wed Oct 07, 2020 16:35
Successful Drosophila cell culture relies on media containing xenogenic components such as fetal bovine serum to support continuous cell proliferation. Here, we report a serum-free culture condition that supports the growth and proliferation of Drosophila S2R+ and Kc167 cell lines. Importantly, the gradual adaptation of S2R+ and Kc167 cells to a media lacking serum was supported by supplementing the media with adult Drosophila soluble extract, commonly known as fly extract. The utility of these adapted...
00:53
Nociceptive neurons of Drosophila melanogaster larvae are characterized by highly branched dendritic processes whose proper morphogenesis relies on a large number of RNA-binding proteins. Post-transcriptional regulation of RNA in these dendrites has been found to play an important role in their function. Here, we investigate the neuronal functions of two putative RNA modification genes, RluA-1 and RluA-2, which are predicted to encode pseudouridine synthases. RluA-1 is specifically expressed in larval...
00:53
The accumulation of biological and biomedical literature outpaces the ability of most researchers and clinicians to stay abreast of their own immediate fields, let alone a broader range of topics. Although available search tools support identification of relevant literature, finding relevant and key publications is not always straightforward. For example, important publications might be missed in searches with an official gene name due to gene synonyms. Moreover, ambiguity of gene names can result...
00:53
Seed vigor is crucial for crop early establishment in the field and is particularly important for forage crop production. Oat (Avena sativa L.) is a nutritious food crop and also a valuable forage crop. However, little is known about the genetics of seed vigor in oats. In order to investigate seed vigor-related traits and their genetic architecture in oats, we developed an easy-to-implement image-based phenotyping pipeline and applied it to 650 elite oat lines from the Collaborative Oat Research...
00:53
British Journal of Cancer, Published online: 08 October 2020; doi:10.1038/s41416-020-01113-yIncreased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
03:00
Abstract Plasma-functionalized liquids (PFL) emerge as an effective sanitizer with great potential to be against a variety of microorganisms but their applications on seafood products are limited. In the current study, the physicochemical properties of plasma-functionalized water (PFW) and plasma-functionalized buffer (PFB), and their antimicrobial activities on grass carp, were investigated under different conditions of applied voltage, plasma exposure time and immersion time....
03:00
Purpose: The DNA Damage Immune Response (DDIR) assay was developed in breast cancer (BC) based on biology associated with deficiencies in homologous recombination and Fanconi Anemia (HR/FA) pathways. A positive DDIR call identifies patients likely to respond to platinum-based chemotherapies in breast and oesophageal cancers. In colorectal cancer (CRC) there is currently no biomarker to predict response to oxaliplatin. We tested the ability of the DDIR assay to predict response to oxaliplatin-based...
Wed Oct 07, 2020 15:50
Purpose: CD19-specific chimeric antigen receptor (CAR)-T cell therapy is effective against refractory or relapsed (R/R) B-cell lymphoma, but the efficacy is hindered by the existence of PD-1/PD-L1 pathway. Experimental Design: Here we generated a novel anti-CD19 CAR expressing PD-1/CD28 chimeric switch-receptor (CD19-PD-1/CD28-CAR). We then conducted a phase 1b study to evaluate safety and efficacy of CD19-PD-1/CD28-CAR T cells in the treatment of PD-L1+ B-cell lymphoma. Results: We found that CD19-PD-1/CD28-CAR...
Wed Oct 07, 2020 15:50
Purpose Osimertinib is a potent and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood brain barrier (BBB) permeability is considered desirable for increasing clinical efficacy. Experimental Design We examined the level of brain penetration for 16 irreversible and reversible EGFR-TKIs using multiple in-vitro and in-vivo BBB preclinical models. Results In-vitro osimertinib...
Wed Oct 07, 2020 15:50
Purpose: To compare the clinical characteristics and overall survival (OS) of germline mutation carriers in homologous recombination repair (HRR) genes and non-carriers with pancreatic ductal adenocarcinoma (PDAC). Methods: Germline DNA from 3,078 patients with PDAC enrolled in a prospective registry at Mayo Clinic between 2000 and 2017 was analyzed for mutations in 37 cancer predisposition genes. Characteristics and OS of patients with mutations in 8 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, PALB2,...
Wed Oct 07, 2020 15:50
Purpose: Heterogeneity in glioblastomas is associated with poorer outcomes, and physiologic heterogeneity can be quantified with non-invasive imaging. We developed spatial habitats based on multiparametric physiologic magnetic resonance imaging (MRI) and evaluated associations between temporal changes in these habitats and progression-free survival (PFS) after concurrent chemoradiotherapy (CCRT) in patients with glioblastoma. Experimental Design: Ninety-seven patients with IDH-wild type glioblastoma...
Wed Oct 07, 2020 15:50
Purpose: Multi-site stereotactic body radiotherapy followed by pembrolizumab (SBRT+P) has demonstrated safety in advanced solid tumors (AST). However, no studies have examined the relationships between irradiated tumor response, SBRT-induced tumor gene expression, and overall survival (OS). Experimental Design: Patients with AST received SBRT (30-50 Gy in 3-5 fractions) to 2-4 metastases followed by pembrolizumab (200mg IV every 3 weeks). SBRT was prescribed to a maximum tumor volume of 65cc....
Wed Oct 07, 2020 15:50
Purpose: Multigene assays provide useful prognostic information regarding hormone receptor (HR)-positive breast cancer. Next-generation sequencing (NGS)-based platforms have numerous advantages including reproducibility and adaptability in local laboratories. This study aimed to develop and validate an NGS-based multigene assay to predict the distant recurrence risk. Experimental Design: In total, 179 genes including 30 reference genes highly correlated with the 21-gene recurrence score (RS) algorithm...
Wed Oct 07, 2020 15:50
Purpose: We aimed to assess the concordance of colorectal cancer (CRC)-associated methylated DNA markers (MDMs) in primary and metastatic CRC for feasibility in detection of distantly recurrent/metastatic CRC in plasma. Experimental Design: A panel of previously discovered CRC-associated MDMs was selected. MDMs from primary and paired metastatic CRC tissue were assayed with quantitative methylation-specific PCR. Plasma MDMs were measured blindly by target enrichment long-probe quantitative amplified...
Wed Oct 07, 2020 15:50
In March 2020, when there were 30,000 confirmed Covid-19 cases in the United States, one of us wrote about the pandemic’s effects on undocumented immigrants. By August, there were about 50,000 new U.S. cases per day, and we had spent several months caring for patients with Covid-19. Today,…
Wed Oct 07, 2020 03:00
Abstract Point-based rigid registration (PBRR) techniques are widely used in many aspects of image-guided surgery (IGS). Accurately estimating target registration error (TRE) statistics is of essential value for medical applications such as optically surgical tool-tip tracking and image registration. For example, knowing the TRE distribution statistics of surgical tool tip can help the surgeon make right decisions during surgery. In the meantime, the pose of a surgical tool is...
03:00
We propose a model for the replication of primordial protocell genomes that builds upon recent advances in the nonenzymatic copying of RNA. We suggest that the original genomes consisted of collections of oligonucleotides beginning and ending at all possible positions on both strands of one or more virtual circular sequences. Replication is driven by feeding with activated monomers and by the activation of monomers and oligonucleotides in situ. A fraction of the annealed configurations of the protocellular...
Wed Oct 07, 2020 18:32
Identifying small molecules that selectively bind an RNA target while discriminating against all other cellular RNAs is an important challenge in RNA-targeted drug discovery. Much effort has been directed toward identifying drug-like small molecules that minimize electrostatic and stacking interactions that lead to non-specific binding of aminoglycosides and intercalators to many stem-loop RNAs. Many such compounds have been reported to bind RNAs and inhibit their cellular activities. However,...
Wed Oct 07, 2020 20:15
Undifferentiated carcinoma of the esophagus and gastroesophageal junction is a recently recognized entity in the fifth edition of the World Health Organization Classification of Digestive Tumors and is diagnostically challenging, particularly on small biopsies. SMARCA4 and SMARCA2 are chromatin remodeling genes with key roles in oncogenesis. We retrieved 14 cases of SMARCA4/SMARCA2-deficient undifferentiated carcinoma of the gastroesophageal junction and esophagus from the authors’ institutions....
Tue Oct 06, 2020 03:00
Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including an EWSR1-rearranged clear cell variant. Myoepithelial carcinoma is generally aggressive with largely unknown genetic features. A retrospective review of Salivary Gland Tumor Registry in Pilsen searching for the key words “clear cell myoepithelial carcinoma,” “hyalinizing clear cell,” and “clear cell malignant myoepithelioma” yielded 94 clear cell myoepithelial carcinomas...
Tue Oct 06, 2020 03:00
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Fri Oct 02, 2020 03:00
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Fri Oct 02, 2020 03:00
Antimicrobial therapeutic treatments are by definition applied after the onset of symptoms, which tend to correlate with infection severity. Using mathematical epidemiology models, I explore how this link affects the coevolutionary dynamics between the virulence of an infection, measured via host mortality rate, and its susceptibility to chemotherapy. I show that unless resistance pre-exists in the population, drug-resistant infections are initially more virulent than drug-sensitive ones. As the...
Wed Oct 07, 2020 03:00
Biodiversity in southwestern North America has a complex biogeographic history involving tectonism interspersed with climatic fluctuations. This yields a contemporary pattern replete with historic idiosyncrasies often difficult to interpret when viewed from through the lens of modern ecology. The Aspidoscelis tigris (Tiger Whiptail) complex (Squamata: Teiidae) is one such group in which potential taxonomic boundaries have been confounded by a series of complex biogeographic processes that have defined...
Wed Oct 07, 2020 03:00
The rooting of the SARS-CoV-2 phylogeny is important for understanding the origin and early spread of the virus. Previously published phylogenies have used different rootings that do not always provide consistent results. We investigate several different strategies for rooting the SARS-CoV-2 tree and provide measures of statistical uncertainty for all methods. We show that methods based on the molecular clock tend to place the root in the B clade, while methods based on outgroup rooting tend to place...
Wed Oct 07, 2020 03:00
The malaria vector, Anopheles stephensi, which is typically restricted to South Asia and the Middle East, was recently detected in the Horn of Africa. Controlling the spread of this vector could involve integrated vector control that considers the status of insecticide resistance of multiple vector species in the region. Previous reports indicate that the knockdown resistance mutations (kdr) in the voltage-gated sodium channel (vgsc) are absent in both pyrethroid resistant and sensitive variants...
Wed Oct 07, 2020 03:00
Chromosome number is a central feature of eukaryote genomes. Deciphering patterns of chromosome-number change along a phylogeny is central to the inference of whole genome duplications and ancestral chromosome numbers. ChromEvol is a probabilistic inference tool that allows the evaluation of several models of chromosome-number evolution and their fit to the data. However, fitting a model does not necessarily mean that the model describes the empirical data adequately. This vulnerability may lead...
Wed Oct 07, 2020 03:00
What are the mechanisms that allow species to extend their ranges and adapt to the novel environmental conditions they find in the newly available habitat? The study of parallel adaptation of pairs of populations to similar environments can provide great insights into this question. Here, we test for parallel evolution driven by niche specialization in a highly social marine mammal, the common bottlenose dolphin, Tursiops truncatus, and investigate the origins of the genetic variation driving local...
Wed Oct 07, 2020 03:00
A major objective of evolutionary biology is to understand the processes by which organisms have adapted to various environments, and to predict the response of organisms to new or future conditions. The availability of large genomic and environmental data sets provides an opportunity to address those questions, and the R package LEA has been introduced to facilitate population and ecological genomic analyses in this context. By using latent factor models, the program computes ancestry coefficients...
Wed Oct 07, 2020 03:00
Replacement of synthetic insecticides with transgenic crops for pest management has been both economically and environmentally beneficial. These benefits have often eroded as pests evolved resistance to the transgenic crops, but a broad understanding of the timing and complexity of the adaptive changes which lead to field-evolved resistance in pest species is lacking. Wild populations of Helicoverpa zea, a major lepidopteran crop pest and the target of transgenic Cry toxin-expressing cotton and corn,...
Wed Oct 07, 2020 03:00
Haplodiploidy and paternal genome elimination (HD/PGE) are common in animals, having evolved at least two dozen times. HD/PGE typically evolves from male heterogamety (i.e., systems with X chromosomes), however why X chromosomes are important for the evolution of HD/PGE remains debated. The Haploid Viability Hypothesis argues that X chromosomes promote the evolution of male haploidy by facilitating purging recessive deleterious mutations. The Intragenomic Conflict Hypothesis instead argues that X...
Wed Oct 07, 2020 03:00
Abstract Background Iron deficiency anemia, pregnancy, and end-stage renal disease (ESRD) are common causes of secondary restless legs syndrome (RLS). Serum ferritin is considered the most specific test associated with the total amount of body iron stores. However, due to the increase of serum ferritin secondary to inflammation in chronic hemodialysis (HD) patients, serum ferritin test results do not fully reflect decreased iron stores...
Wed Oct 07, 2020 03:00
Abstract Purpose Colorectal cancer (CRC) is one of the common causes of cancer death worldwide. Obstructive sleep apnea syndrome (OSAS), sharing many risk factors in common with CRC, is prevalent among CRC patients. OSAS may promote the CRC development independently but the mechanism is still unknown. Intermittent hypoxia (IH) is one of the characteristics of OSAS, and hypoxia may influence the genes associated with CRC. Intestinal...
Wed Oct 07, 2020 03:00
Abstract Purpose To determine the prevalence of poor sleep quality and RLS in adult patients with sickle cell anemia (SCA). The second aim was to identify the risk factors for RLS and impairment of sleep quality in SCA patients. Materials and methods Patients at least 18 years old, with hemoglobin electrophoresis confirmation of sickle cell disease,...
03:00
Abstract Purpose Total and partial proximal catheter occlusions are well-known complications of ventriculoperitoneal shunts (VPS). When this occurs, surgeons often attempt to perform a shunt tap. However, the degree of obstruction in a proximal catheter that ultimately leads to shunt malfunction is unknown. Methods We developed a benchtop model to...
Wed Oct 07, 2020 03:00
Abstract Background Growing skull fracture (GSF) is a rare condition that may complicate pediatric head trauma. Patients may present with delayed-onset neurological manifestations. Aim This study aims to highlight the different presentations, methods of evaluation, treatment modalities, and outcomes in patients with orbital roof GSF. ...
Wed Oct 07, 2020 03:00
Abstract Spinal neurocytoma (SN), although frequently reportedly as tumors of the central nervous system (CNS), are a distinct class of tumors, which can achieve a better prognosis following subtotal or gross total tumor resection. Nonetheless, even with the premise of successful treatment after tumor resection, poor prognosis after treatment due to the SN high proliferation index (typically known as atypical SN) have been reported. Over the past two decades, atypical SN was only...
03:00
This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein–protein interaction network.
Wed Oct 07, 2020 03:00
This study was designed to facilitate genetic studies that would allow information on population structure and genetic diversity of natural or captive stocks of paca (Cuniculus paca), a species of ecological and ...
Wed Oct 07, 2020 03:00
Approximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achi...
Wed Oct 07, 2020 03:00
Compared to other stem cells, the multipotency of human adipose-derived mesenchymal stem cells (ASCs) is limited. Effective approaches that trigger or enhance lineage-specific transdifferentiation are highly e...
Wed Oct 07, 2020 03:00
Respiratory tract diseases (RTDs) are among the top five leading causes of death worldwide. Mortality rates due to respiratory tract diseases (MRRTDs) follow a spatial pattern and this may suggest a potential ...
Wed Oct 07, 2020 03:00
One third of the Australian work force are immigrants. Relatively little is known about working conditions for specific migrant groups. The objectives of this paper are to describe and compare the sampling str...
Wed Oct 07, 2020 03:00
Prenatal diagnosis has historically been performed with the use of G-banded karyotyping to detect chromosomal abnormalities. This approach results in a diagnosis in 9 to 19% of fetal anomalies, and chromosomal microarray analysis provides an additional 6% yield. Therefore, the cause of the majority…
Wed Oct 07, 2020 03:00
Over the past two decades, emerging coronaviruses (CoVs) have caused three major outbreaks — severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (Covid-19). Since MERS was reported in Saudi Arabia in 2012, at least 2494 cases and 858…
Wed Oct 07, 2020 03:00
Summary Childhood severe obesity is a serious, urgent and complex global health problem with long‐term co‐morbidities. Obstructive sleep‐disordered breathing is more common in obese children and adolescents. Increased body mass index is associated with an increase in apnea−hypopnea index. Obstructive sleep apnea leads to a decrease in rapid eye movement sleep, and obese children have been noted to have a decrease in rapid eye movement sleep, leading to weight gain. Short sleep duration and poor...
Wed Oct 07, 2020 15:43
Peanut allergy (PA) has increased in developed countries and can have a dramatic effect on quality of life but data surrounding this is limited in France. Allergy to Peanuts imPacting Emotions And Life study (...
Wed Oct 07, 2020 03:00
Abstract Background and purpose Aβ1–42-induced neurotoxicity has been considered as a possible mechanism to aggravate the onset and progression of Alzheimer’s disease (AD). In this study, we aim to determine the protective effect of DMDD on the apoptosis of SH-SY5Y cells induced by Aβ1–42 and elucidate potential mechanism of DMDD’s protective function in apoptosis. Experimental...
03:00
Prenatal diagnosis has historically been performed with the use of G-banded karyotyping to detect chromosomal abnormalities. This approach results in a diagnosis in 9 to 19% of fetal anomalies, and chromosomal microarray analysis provides an additional 6% yield. Therefore, the cause of the majority…
Wed Oct 07, 2020 03:00
Nonimmune hydrops fetalis (NIHF) has a striking appearance on ultrasonography and is classically defined by the presence of pathologic fluid accumulation in at least two fetal sites, including the serous cavities (pericardial, pleural, and peritoneal), with associated skin edema. Its diagnosis is…
Wed Oct 07, 2020 03:00
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