Wed Jul 01, 2020 18:24
Related Articles The Usefulness of Esophageal Baseline Impedance Levels for the Diagnosis of Nonerosive Reflux Disease and the Proper Time for Measurement in Endoscopy-negative Korean Patients With Esophageal or Supraesophageal Symptoms. J Neurogastroenterol Motil. 2020 Jun 29;: Authors: Kim YG, Noh CK, Lee KJ Abstract Background/Aims: Baseline impedance levels (BILs) have been suggested to be evidence of GERD. The aim of this study is to investigate...
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Tissue Engineering Part A, Ahead of Print.
Tue Jun 30, 2020 10:00
Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo
Tissue Engineering Part A, Ahead of Print.
Mon Jun 29, 2020 10:00
Surgical Infections, Ahead of Print.
Fri Jun 26, 2020 10:00
Surgical Infections, Ahead of Print.
Tue Jun 30, 2020 10:00
Presentation of Case. Dr. Aditya Bardia: A 62-year-old woman was evaluated at this hospital after she had identified a mass in her left breast, confirmed by her physician on physical examination, during the pandemic of coronavirus disease 2019 (Covid-19), the disease caused by severe acute…
Wed Jul 01, 2020 03:00
Abstract The Melanocortin‐1 receptor (MC1R) belongs to the family of the G protein Coupled Receptor (GPCR). Activated GPCRs can promote the phosphoinositide 3‐kinase (PI3K) pathway. Few studies deal with the role of the PI3K‐pathway activation in response to αMSH. On B16‐F10 cell line, we investigated the αMSH‐dependent modulation of pAKT/AKT, as a key element of the PI3K pathway after rapid and prolonged stimulation. We demonstrated that αMSH triggers a rapid modulation of AKT which culminates...
Tue Jun 30, 2020 20:24
Summary The 2019 revised NICE guidance (TA566) on cochlear implantation (CI) lowered the audiological threshold at which patients become eligible for CI. NICE estimates this will result in a 70% increase in CI by 2024/25. We performed a retrospective audit of all audiograms performed at East Kent Hospitals University Foundation Trust (serving a population of 695,000 people) over the last 6 years. We identified how many patients were eligible for CI using both the 2009 guidelines and the...
Wed Jul 01, 2020 22:58
Abstract There were 24,719 emergency admissions for epistaxis in English NHS trusts from April 2017‐April 2018.1 Epistaxis is initially managed with external nasal pressure and ice, then cautery, nasal packing, surgery or embolisation, in ascending order. There is growing evidence for Floseal use in anterior and posterior epistaxis. Floseal is a hydrophilic, biodegradable matrix haemosealant. The keyreported benefits of Floseal use include: high patient tolerance compared tonasal packing; good...
Wed Jul 01, 2020 22:18
Abstract The article by Bird et al, is an interesting read and I wish to strongly support their recommendations of a more coherent multidisciplinary approach to dysphagia1. UEMS‐ORL are currently in the early stages of forming either an MJC (Multidisciplinary Joint Committee) in Swallowing Disorders or a Thematic Federation in Dysphagia with European colleagues in other relevant specialties and this publication will certainly assist our endeavours.
Tue Jun 30, 2020 18:03
Abstract Try as we might to make the manuscript selection process as objective as possible, the crapshoot element is unquestionable. Prospective papers are being submitted more frequently than ever, which has broadened the number of reviewers. Medical students and senior faculty alike are being tasked with assessing manuscripts. Different levels of experience, knowledge and variable personal research interests introduce undeniable biases in how papers are ultimately critiqued.
Tue Jun 30, 2020 17:45
Thyroid, Ahead of Print.
Tue Jun 30, 2020 10:00
Thyroid, Ahead of Print.
Mon Jun 29, 2020 10:00
Abstract Brain mitochondrial function is critical for numerous neuronal processes. We recently identified a link between brain energy and social dominance, where higher levels of mitochondrial function resulted in increased social competitive ability. The underlying mechanism of this link, however, remains unclear. Here we investigated the contribution of astrocytic release of adenosine triphosphate (ATP) through the type 2 inositol 1,4,5‐triphosphate receptor to social dominance behavior. Mice...
Wed Jul 01, 2020 22:48
Abstract The input structure of the basal ganglia, striatum, receives dense neuromodulatory input in the form of dopamine and acetylcholine. The two systems are tightly connected, e.g. synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. Both signals are further needed for induction of locomotion. High dopamine concentration leads to increased excitability of the...
Wed Jul 01, 2020 11:09
Abstract Objectives The purpose of this preliminary study was to explore blood microcirculation and somatosensory profiles in periodontitis patients before and after non-surgical periodontal therapy. Materials and methods Twenty patients (10 men and 10 women, 20 to 30 years old) and 20 age- and gender-matched healthy controls were included. Non-surgical periodontal...
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Abstract Objectives The present investigation aimed to evaluate the subjective perception of deformational cranial asymmetries by different observer groups and to compare these subjective perceptions with objective parameters. Materials and methods The 3D datasets of ten infants with different severities of deformational plagiocephaly (DP) were presented...
Wed Jul 01, 2020 03:00
Abstract Background Women experiencing unintended and short-interval pregnancies are at increased risk for adverse outcomes. Nationally, researchers report disparities in women’s use of effective contraceptive methods based on demographic, cultural, financial and system-level factors. Despite 58% of Louisiana births being unplanned, researchers have not reported on these relationships in Louisiana. ...
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Related Articles Upright positioning-related reverse nystagmus in posterior canal benign paroxysmal positional vertigo and its effect on prognosis. J Vestib Res. 2020 Jun 22;: Authors: Jafarov S, Hizal E, Bahcecitapar M, Ozluoglu LN Abstract BACKGROUND: Positional nystagmus elicited by the Dix-Hallpike maneuver often reverses its direction as the patient is re-seated from the provoking head hanging position. The incidence of reverse nystagmus...
05:23
Oncogenesis, Published online: 01 July 2020; doi:10.1038/s41389-020-00246-2Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation
Wed Jul 01, 2020 03:00
Wed Jul 01, 2020 03:00
Whole-genome duplication (WGD) is hypothesized to be an important evolutionary mechanism that can facilitate adaptation and speciation. Genomes that exist in states of both diploidy and residual tetraploidy are of particular interest, as mechanisms that maintain the ploidy mosaic after WGD may provide important insights into evolutionary processes. The Salmonidae family exhibits residual tetraploidy, and this, combined with the evolutionary diversity formed after an ancestral autotetraploidization...
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Key points Age‐related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age‐related changes occurring in the auditory sensory cells, including those associated with the outer hair cells (OHCs). Using different mouse strains, we show that OHCs undergo several morphological and biophysical changes in the ageing cochlea. Ageing OHCs also exhibited...
Wed Jul 01, 2020 22:35
Tue Jun 30, 2020 16:56
Tue Jun 30, 2020 16:54
Key points Thalamic activity is regulated by corticothalamic feedback from layers 5B and 6. To selectively study the importance of the layer 6 corticothalamic (L6 CT) projection a transgenic mouse line was used in which layer 6 cells projecting to posterior medial thalamus (POm) were targeted for expression of channelrhodopsin‐2. Repetitive optogenetic stimulation of this sub‐type of L6 cells caused a rapid adaptation in POm spiking output, but had little effect on the spiking activity in the...
Tue Jun 30, 2020 15:20
Abstract Primates often consume either bark or cambium (inner bark) as a fallback food to complete their diet during periods of food scarcity. Wild chimpanzees exhibit great behavioral diversity across Africa, as studies of new populations frequently reveal. Since 2014, we have been using a combination of camera traps and indirect signs to study the ecology and behavior of wild chimpanzees (Pan troglodytes verus) in Comoé National Park, Ivory Coast, to document and understand...
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Abstract Primates are sometimes categorized in terms of their habitat. Although such categorization can be oversimplistic, there are scientific benefits from the clarity and consistency that habitat categorization can bring. Chimpanzees (Pan troglodytes) inhabit various environments, but researchers often refer to “forest” or “savanna” chimpanzees. Despite the wide use of this forest–savanna distinction, clear definitions of these landscapes for chimpanzees, based on environmental...
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Related Articles Integrated Bioinformatics Analysis of mRNAs and miRNAs Identified Potential Biomarkers of Oral Squamous Cell Carcinoma. Asian Pac J Cancer Prev. 2020 Jun 29;21(6):1841-1848 Authors: Amiri-Dashatan N, Koushki M, Jalilian A, Ahmadi NA, Rezaei-Tavirani M Abstract Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being the eighth most common type of human malignancy worldwide. Despite improvement...
04:44
RNA structure influences numerous processes in all organisms. In bacteria, these processes include transcription termination and attenuation, small RNA and protein binding, translation initiation, and mRNA stability, and can be regulated via metabolite availability and other stresses. Here we use Structure-seq2 to probe the in vivo RNA structurome of Bacillus subtilis grown in the presence and absence of amino acids. Our results reveal that amino acid starvation results in lower overall dimethyl...
Wed Jul 01, 2020 18:48
Abstract Background/objectives Sleep disorders are highly prevalent in primary care. Obstructive sleep apnea (OSA) is one of the most common sleep disorders in the world, and it is estimated that only 10 to 20% of OSA cases are diagnosed. Primary care physicians (PCP) play an important role in screening for OSA. Knowledge of sleep disorders among PCP varies widely and has been generally reported as low. In this study, we aimed to assess...
Wed Jul 01, 2020 03:00
Purpose: To evaluate the prognostic value of post-treatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, to the standard contrast agent, Gd-DOTA, for their abilities to identify FOLFIRINOX-induced fibrosis in a murine model of PDAC. Experimental Design: Ninety-three chemoradiation-treated human PDAC samples were stained for fibrosis and outcomes evaluated. For imaging, C57BL/6 mice were orthotopically implanted with PDAC cells and FOLFIRINOX was administered....
Wed Jul 01, 2020 16:39
Purpose: Preclinical studies show that adavosertib, a WEE1 kinase inhibitor, sensitizes TP53-mutant cells to chemotherapy. We hypothesized that adavosertib, plus chemotherapy, would enhance efficacy versus placebo in TP53-mutated ovarian cancer. Methods: Following safety run-in, this double-blind Phase II trial (NCT01357161) randomized women with TP53-mutated, platinum-sensitive ovarian cancer to oral adavosertib (225 mg twice daily for 2.5 days/21-day cycle) or placebo, plus carboplatin (AUC5) and...
Wed Jul 01, 2020 16:39
A supervised machine learning model was developed that utilized FLIP panometry parameters to distinguish type III achalasia from non‐spastic achalasia. These approaches can be applied to detect achalasia subtypes using FLIP panometry and may also complement HRM to identify specific clinical phenotypes of achalasia. Abstract Background Achalasia subtypes on high‐resolution manometry (HRM) prognosticate treatment response and help direct management plan. We aimed to utilize parameters of distension‐induced...
Wed Jul 01, 2020 22:19
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