Related Articles Application of a Novel Metallomics Tool to Probe the Fate of Metal-Based Anticancer Drugs in Blood Plasma: potential, challenges and prospects. Curr Top Med Chem. 2020 Jun 27;: Authors: Sarpong-Kumankomah S, Gailer J Abstract Although metallodrugs are in use to treat a variety of human disorders and exhibit a remarkable diversity of therapeutic properties, they constitute only a tiny minority of all medicinal drugs that are...
Wed Jul 01, 2020 13:02
Related Articles Synthesis, evaluation of antimicrobial activity and molecular docking of new N-1,3-thiazol-2-ylacetamides of condensed pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidines. Curr Top Med Chem. 2020 Jun 28;: Authors: Sirakanyan S N, Kartsev V G, Geronikaki A, Spinelli D, Petrou A, Hakobyan E K, Glamoclija Ja, Ivanov M, Sokovic M, Hovakimyan A A Abstract BACKGROUND: From the literature it is known that many derivatives of fused thienopyrimidines...
Wed Jul 01, 2020 13:02
Related Articles Identification and characterization of Lipopeptide Biosurfactant producing Microbacterium sp isolated from brackish river water. Curr Top Med Chem. 2020 Jun 28;: Authors: Nayarisseri A, Khandelwal R, Singh SK Abstract BACKGROUND: Bioremediation has taken its call for removing pollutants for years. The oil-contaminated surroundings are majorly hazardous for sustaining life but there has been a great contribution of nature in...
Wed Jul 01, 2020 13:02
Related Articles Lineage-restricted sympathoadrenal progenitors confer neuroblastoma origin and its tumorigenicity. Oncotarget. 2020 Jun 16;11(24):2357-2371 Authors: Yang CL, Serra-Roma A, Gualandi M, Bodmer N, Niggli F, Schulte JH, Bode PK, Shakhova O Abstract Neuroblastoma (NB) is the most common cancer in infants and it accounts for six percent of all pediatric malignancies. There are several hypotheses proposed on the origins of NB. While...
Wed Jul 01, 2020 13:00
Related Articles Preoperative geriatric nutritional risk index is a useful prognostic indicator in elderly patients with gastric cancer. Oncotarget. 2020 Jun 16;11(24):2345-2356 Authors: Hirahara N, Matsubara T, Fujii Y, Kaji S, Hyakudomi R, Yamamoto T, Uchida Y, Miyazaki Y, Ishitobi K, Kawabata Y, Tajima Y Abstract BACKGROUND: The geriatric nutritional risk index (GNRI) was developed to evaluate the prognosis in elderly hospitalized patients...
Wed Jul 01, 2020 13:00
Related Articles Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity. Oncotarget. 2020 Jun 16;11(24):2327-2344 Authors: Bhattacharyya S, Feferman L, Han X, Xia K, Zhang F, Linhardt RJ, Tobacman JK Abstract Expression of CHST15 (carbohydrate sulfotransferase 15; chondroitin 4-sulfate-6-sulfotransferase; BRAG), the sulfotransferase...
Wed Jul 01, 2020 13:00
Related Articles Preliminary safety and imaging efficacy of the near-infrared fluorescent contrast agent DA364 during fluorescence-guided surgery in dogs with spontaneous superficial tumors. Oncotarget. 2020 Jun 16;11(24):2310-2326 Authors: Favril S, Brioschi C, Vanderperren K, Abma E, Stock E, Devriendt N, Polis I, De Cock H, Cordaro A, Miragoli L, Oliva P, Valbusa G, Alleaume C, Tardy I, Maiocchi A, Tedoldi F, Blasi F, de Rooster H Abstract ...
Wed Jul 01, 2020 13:00
Related Articles Validated limited gene predictor for cervical cancer lymph node metastases. Oncotarget. 2020 Jun 16;11(24):2302-2309 Authors: Bloomstein JD, von Eyben R, Chan A, Rankin EB, Fregoso DR, Wang-Chiang J, Lee L, Xie LX, David SM, Stehr H, Esfahani MS, Giaccia AJ, Kidd EA Abstract PURPOSE: Recognizing the prognostic significance of lymph node (LN) involvement for cervical cancer, we aimed to identify genes that are differentially...
Wed Jul 01, 2020 13:00
Related Articles SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model. Oncotarget. 2020 Jun 16;11(24):2290-2301 Authors: Sheets JN, Patrick ME, Egland KA Abstract The cause of death among high-grade serous ovarian cancer (HGSOC) patients involves passive dissemination of cancer cells within the peritoneal cavity and subsequent implantation of cancer spheroids...
Wed Jul 01, 2020 13:00
Related Articles The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers. Oncotarget. 2020 Jun 16;11(24):2273-2289 Authors: Vermehren-Schmaedick A, Mhawech-Fauceglia P, Park BS, Pejovic T, Luoh SW Abstract Objective: To study GRB7 protein expression in normal human tissues and breast and ovarian cancers, and determine its clinical significance. Results: GRB7 protein was expressed in multiple...
Wed Jul 01, 2020 13:00
Related Articles Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity. Oncotarget. 2020 Jun 16;11(24):2262-2272 Authors: Marsden CG, Jaruga P, Coskun E, Maher RL, Pederson DS, Dizdaroglu M, Sweasy JB Abstract Oxidatively-induced DNA damage, widely accepted as a key player in the onset of cancer, is predominantly...
Wed Jul 01, 2020 13:00
Herbicides are important tools for weed control in modern agriculture. In the search for potential herbicidal natural products from fungal species, harzianum A and B were identified from the biofertilizer fung...
Wed Jul 01, 2020 03:00
The fungal kingdom has been widely studied as a source of bioactive compounds of interest to the pharmaceutical and food industry. This paper studies the production of natural red pigments by Fusarium solani BRM0...
Wed Jul 01, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00713G, PaperFlorian Lotz, Stefanie Gerbig, Christian Lotze, Bernhard Spengler, Sabine SchulzA general-purpose desorption electrospray ionization (DESI) source is presented which is not bound to the laboratory site. It allows autarkic operation for a few hours and can be connected to...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jul 01, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN90071K, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mengyuan He, Ning Shang, Lin Shen, Zhihong LiuTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jul 01, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00998A, PaperKoki Yamamoto, Kyojiro Morikawa, Hiroyuki Imanaka, Koreyoshi Imamura, Takehiko KitamoriSingle-cell analyses have recently become important to understand cell heterogeneity, the mechanism of cell function, and diseases. In contrast to single-cell analyses that target nucleic acids, single-cell protein analyses still...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jul 01, 2020 02:00
Abstract Evidence suggests peripheral autonomic structures may contribute to autonomic dysfunction in idiopathic rapid eye movement sleep behaviour disorder (iRBD). However, whether the central autonomic network (CAN) is affected in iRBD remains unclear. Magnetic resonance imaging data were acquired from 65 participants (32 patients with iRBD and 33 matched healthy controls). We investigated the CAN in patients with iRBD using a combined voxel‐based morphometry and resting‐state functional connectivity...
Tue Jun 30, 2020 18:59
Abstract Background Most skin paddles of the fibula flap are harvested from the distal third of the lower leg, skin grafting for the donor‐site is necessary. Methods A retrospective review was done on patients with large bony defects using free fibula osteocutaneous flaps (FOSCFF) for head and neck reconstruction. We focus on the techniques for closure of donor sites were skin grafting, primary closure with tear drop design and propeller flap technique on the donor site closure using skin...
Tue Jun 30, 2020 16:06
Abstract Objective The admission interview in oncological inpatient rehabilitation might be a good opportunity to identify cancer patients' needs present after acute treatment. However, a relevant number of patients may not express their needs. In this study, we examined (1) the proportion of cancer patients with unexpressed needs, (2) topics of unexpressed needs and reasons for not expressing needs, (3) correlations of not expressing needs with several patient characteristics, and (4) predictors...
Tue Jun 30, 2020 12:15
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that can arise throughout the gastrointestinal tract. These tumors represent less than 0.1% of all gastric polypoid lesions and are frequently found incidentally on endoscopic evaluation. While presenting symptoms depend on the location of the tumor, gastric polyps commonly present with epigastric pain and early satiety. We hereby delineate...
Tue Jun 30, 2020 13:26
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Nocardia brasiliensis is the most common cause of cutaneous nocardiosis. Nocardia pseudobrasiliensis is an emerging species responsible for invasive and disseminated disease in immunocompromised patients. We describe a case of a 67-year-old immunocompetent patient without significant past medical history diagnosed with primary cutaneous nocardiosis with N pseudobrasiliensis as the causative organism....
Tue Jun 30, 2020 13:20
Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Remote models of pulmonary rehabilitation (PR) are vital with suspension of face-to-face activity during the COVID-19 pandemic. We surveyed digital access and behaviours and PR delivery preferences of current PR service users. There was significant heterogeneity in access to and confidence in using the Internet with 31% having never previously accessed the Internet, 48% confident using the Internet and 29% reporting no interest...
Tue Jun 30, 2020 15:25
The study aimed to evaluate to which extent self-reported symptomatology, age, and sex are predictors of titanium and nickel allergic sensitization in patients in treatment with fixed orthodontic appliances.
Wed Jul 01, 2020 03:00
Objectives Cortical demyelination is common in multiple sclerosis (MS) and can be extensive. Cortical lesions contribute to disability independently from white matter lesions and may form via a distinct mechanism. However, current magnetic resonance imaging methods at 3 T are insensitive to cortical, and especially subpial cortical, lesions. Subpial lesions are well seen on T2*-weighted imaging at 7 T, but T2*-weighted methods on 3 T scanners are limited by poor lesion-to-cortex and cerebrospinal...
Wed Jun 24, 2020 03:00
Objective Estimations of radiation dose absorbed by the fetus from computed tomography (CT) in pregnant patients is mandatory, but currently available methods are not feasible in clinical routine. The aims of this study were to develop and validate a tool for assessment of fetal dose from CT of pregnant patients and to develop a user-friendly web interface for fast fetal dose calculations. Methods In the first study part, 750 Monte Carlo (MC) simulations were performed on phantoms representing...
Wed Jun 24, 2020 03:00
Objectives In recent years, complaints of patients about burning pain in arms and legs after the injection of gadolinium-based contrast agents (GBCAs) have been reported. In the current study, we investigated changes of small fibers in the epidermis as a potential cause of the patient complaints in a mouse model. Methods Six groups of 8 mice were intravenously injected with either a macrocyclic GBCA (gadoteridol, gadoterate meglumine, gadobutrol), a linear GBCA (gadodiamide or gadobenate...
Wed Jun 24, 2020 03:00
Purpose The aims of this study were to assess radiofrequency (RF) shielding and susceptibility-induced imaging artifacts of venous stents with different designs at 1.5 T and to analyze the relationship between stent designs, that is, cell geometry and RF shielding. Methods Twelve dedicated venous stents and 1 stent used for venous pathologies with 8 different designs from 5 different manufacturers were tested: Blueflow (plus medica, Düsseldorf, Germany), Sinus Obliquus, Sinus Venous,...
Wed Jun 24, 2020 03:00
Objectives The aim of this study was to explore blood deoxygenation across cerebral arteriovenous malformations (AVMs) for functional characterization of AVM vasculature. Materials and Methods Fifteen patients with cerebral arteriovenous vascular malformation were prospectively studied by digital subtraction angiography and using a 3 T magnetic resonance imaging system, with which three-dimensional (3D) gradient echo data for the calculation of quantitative susceptibility maps, velocity-encoded...
Wed Jun 24, 2020 03:00
Abstract Rehabilitation of edentulous maxilla is a challenging procedure. This technical report describes a new method to superimpose intraoral optical scanning of edentulous maxilla and the CBCT scan using a modified radiographic template. Digital data obtained can be exported and merged into 3D computer guided surgery software. The described technique can increase the predictability and the precision of complete‐arch rehabilitation planned by means of computer‐assisted implant surgery. This article...
Tue Jun 30, 2020 20:41
Abstract Purpose To evaluate the in vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with hydrogen peroxide (H2O2) and povidone‐iodine (PVP‐I) oral antiseptic rinses at clinically recommended concentrations and contact times. Materials and Methods SARS‐CoV‐2, USA‐WA1/2020 strain virus stock was prepared prior to testing by growing in Vero 76 cells. The culture media for prepared virus stock was minimum essential medium (MEM) with 2% fetal bovine serum (FBS)...
Tue Jun 30, 2020 20:36
Abstract Purpose Standardized crown preparation is an important competency for prosthodontic faculty especially when they take on the dual role of clinician and clinical teacher. Effects of faculty training for enhancing crown preparation competency are seldom reported. This study aimed to analyze the impact of a standardized training workshop with digital evaluation on the dental faculty's performance in crown preparation. Materials and Methods The digitally evaluated grades of anterior...
Tue Jun 30, 2020 18:55
Purpose: Although programmed death-ligand 1 (PD-L1) antibody–based therapy has improved the outcome of patients with cancer, acquired resistance to these treatments limits their clinical efficacy. FS118 is a novel bispecific, tetravalent antibody (mAb2) against human lymphocyte activation gene-3 (LAG-3) and PD-L1 with the potential to reinvigorate exhausted immune cells and overcome resistance mechanisms to PD-L1 blockade. Here, using FS118 and a murine surrogate, we characterized the activity and...
Wed Jul 01, 2020 10:06
Wed Jul 01, 2020 10:06
Cytarabine is the backbone of AML therapy, but the dose used during induction has remained controversial. Using an intermediate dose of cytarabine, compared with conventional dose, was shown to improve disease-free and overall survival in adult patients in China up to age 55, particularly in patients with intermediate cytogenetic risk. See related article by Wei et al., p. 3154
Wed Jul 01, 2020 10:06
Purpose: Lung squamous cell carcinoma (LSCC) is a deadly disease for which only a subset of patients responds to immune checkpoint blockade (ICB) therapy. Therefore, preclinical mouse models that recapitulate the complex genetic profile found in patients are urgently needed. Experimental Design: We used CRISPR genome editing to delete multiple tumor suppressors in lung organoids derived from Cre-dependent SOX2 knock-in mice. We investigated both the therapeutic efficacy and immunologic effects...
Wed Jul 01, 2020 10:06
Some patients with brain cancer show extremely short survival postradiochemotherapy treatment for unknown reasons. Recent work shows that this is closely linked to encephalopathy associated with reactivation of latent cytomegalovirus in the host. Importantly, survival can be enhanced by treatment with antiviral drugs. See related article by Goerig et al., p. 3259
Wed Jul 01, 2020 10:06
Purpose: Although first-line crizotinib treatment leads to clinical benefit in ROS1+ lung cancer, high prevalence of crizotinib-resistant ROS1-G2032R (ROS1G2032R) mutation and progression in the central nervous system (CNS) represents a therapeutic challenge. Here, we investigated the antitumor activity of repotrectinib, a novel next-generation ROS1/TRK/ALK-tyrosine kinase inhibitor (TKI) in ROS1+ patient-derived preclinical models. Experimental Design: Antitumor activity of repotrectinib...
Wed Jul 01, 2020 10:06
A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effects in these patients. Modern radiotherapy methods can preferentially protect normal tissues from radiation toxicities to permit higher doses to targets. However, concerns about chronic small bowel toxicity, for example, still constrain the prescription dose. This...
Wed Jul 01, 2020 10:06
Purpose: Generation of antigen-specific T cells from patients with cancer employs large numbers of peripheral blood cells and/or tumor-infiltrating cells to generate antigen-presenting and effector cells commonly requiring multiple rounds of restimulation ex vivo. We used a novel paramagnetic, nanoparticle-based artificial antigen-presenting cell (nano-aAPC) that combines anti-CD28 costimulatory and human MHC class I molecules that are loaded with antigenic peptides to rapidly expand tumor antigen–specific...
Wed Jul 01, 2020 10:06
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