Publication date: 1 November 2020Source: Talanta, Volume 219Author(s): Antonios P. Hadjixenis, Jan Hrbac, Mamas I. Prodromidis
Wed Jul 01, 2020 16:32
Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): Nicole M. Herzog, Christopher Parker, Earl Keefe, Kristen Hawkes
Wed Jul 01, 2020 16:31
We present a 56-year-old woman with metastatic follicular thyroid cancer at the nose tip with 131I uptake that is clinically rare, mimicking physiological uptake in the nose, a common finding seen after routine 131I therapeutic imaging. The lesion revealed a metastatic follicular thyroid cancer with 131I uptake and response to 131I therapy. Surgical removal, however, was not performed due to cosmetic and functional considerations. Active surveillance is warranted owing to its relative aggressiveness...
Thu Jun 25, 2020 03:00
Rectal leiomyoma is an exceedingly rare benign lesion. We here report a case with extraluminal leiomyoma of the middle and lower parts of the rectum showing aberrant hypermetabolism on 18F-FDG PET/CT in a 54-year-old man. Received for publication March 15, 2020; revision accepted April 4, 2020. Conflicts of interest and sources of funding: This work was supported by the National Natural Science Foundation of China (no. 81501512). None declared to all authors. Correspondence to: Yong He,...
Thu Jun 25, 2020 03:00
Metastasis to the scrotal sac is a very rare phenomenon. We present a case of a 45-year-old man diagnosed with locally advanced acinar adenocarcinoma prostate, post bilateral orchidectomy and radiotherapy treatment, who showed a rising trend of serum PSA levels with discovery of scrotal sac metastasis on serial 68Ga–prostate-specific membrane antigen PET/CT scans. Received for publication February 7, 2020; revision accepted April 5, 2020. Conflicts of interest and sources of funding: none...
Thu Jun 25, 2020 03:00
Purpose The aim of this study was to investigate the role of 18F-fluciclovine PET/CT in the evaluation of prostate cancer (PC) patients after definitive treatment in the presence of undetectable prostate-specific antigen (PSA). Patients and Methods This retrospective study was conducted in PC patients who had undetectable PSA level and underwent fluciclovine PET/CT within a 2-week interval of PSA examination and without interval treatment or other cancer. Patient and tumor characteristics...
Thu Jun 25, 2020 03:00
Erdheim-Chester disease (ECD) is a rare non–Langerhans cell histiocytic disorder with variable clinical presentation most commonly involving the skeletal system. The long bones are the most common site of involvement giving a characteristic bone scintigraphy pattern of increased bilateral symmetric uptake in metadiaphyseal regions. We describe the findings of serial 18F-FDG PET/CT in a 16-year-old adolescent girl with ECD, emphasizing the role of 18F-FDG PET/CT in response assessment of ECD. Received...
Thu Jun 25, 2020 03:00
Isolated pancreatic metastasis from choroidal melanoma is a rare phenomenon. We describe a case of a 38-year-old woman who underwent enucleation surgery for right choroidal melanoma and subsequently developed lesions in the pancreas 10 years after enucleation, which were depicted on 68Ga-DOTANOC PET/CT and confirmed to be metastasis from choroidal melanoma on surgical histopathology. Received for publication March 30, 2020; revision accepted April 8, 2020. Conflicts of interest and sources...
Thu Jun 25, 2020 03:00
In this case report, we present the bone scintigraphic findings of a 9-year-old boy with Gaucher disease who has a history of fractures to evaluate the extent of his osseous lesions. Gaucher disease is a genetic deficiency of lysosomal enzyme glucocerebrosidase, which results in the accumulation of glucocerebroside in the macrophages in the reticuloendothelial cells of the spleen, liver, and bone marrow. Most patients with type 1 Gaucher disease present a clinical or radiographic evidence of infiltrative...
Thu Jun 25, 2020 03:00
We report the case of an asymptomatic 66-year-old woman referred for initial staging of an invasive ductal breast carcinoma. Initial workup incidentally revealed a bone tumor of right sacral wing corresponding to a giant cell tumor (GCT). We present the imaging characteristics of GCT on 99mTc-HDP bone scan (doughnut sign), 18F-FDG PET/CT (intense and heterogeneous uptake of a prominent geographic lytic lesion with partial rupture of cortical), and MRI (hyposignal with gadolinium enhancement on T1-weighted...
Thu Jun 25, 2020 03:00
Pulmonary artery involvement can occur in about half of the patients suffering Takayasu arteritis. Increased FDG activity in the aorta and its main branches in patients with Takayasu arteritis on PET/CT had been well-reported. However, the FDG PET/CT appearance of pulmonary artery involvement in Takayasu arteritis is less known. We present FDG PET/CT findings in a 37-year-old patient with known Takayasu arteritis. The images showed rim-like FDG activity in opacities in the left lung, which was later...
Thu Jun 25, 2020 03:00
Incidental tracer uptake on DOTATATE PET is increasingly encountered in clinical practice. We describe 3 patients with suspected or known neuroendocrine tumor who were found to have diffuse and intense stomach uptake on DOTATATE PET. All patients underwent esophagogastroduodenoscopy and/or endoscopic ultrasound; the cause of the stomach uptake was attributed to proton-pump inhibitor use, chronic gastritis, and gastrinoma, respectively. These 3 cases highlight that diffuse and intense stomach DOTATATE...
Thu Jun 25, 2020 03:00
Amyloidosis is a disorder resulting from the deposition of fibrillary protein in the extracellular tissue and can be classified into primary, secondary, familial, and senile types. Isolated lymph node amyloidosis without any other organ involvement is very rarely seen in clinical parlance, and diagnosis remains very challenging owing to nonspecific imaging findings. We present a case of 50-year-old man with lymphadenopathy, which was later confirmed to be amyloidosis on biopsy and serum-free light...
Thu Jun 25, 2020 03:00
Introduction Dose response of 22 patients experiencing mCRPC (metastatic castration-resistant prostate cancer) to 177Lu-PSMA I&T radionuclide therapy was investigated. Dosimetry calculations are used to assess correlations between dosimetric quantities and biomarker values. Methods The patients’ age range was 74 ± 7 years at the time of the investigated treatment cycle, and the mean injected activity was 7416 ± 218 MBq. Planar images at several time points postinjection were used...
Thu Jun 25, 2020 03:00
Localized malignant mesothelioma is rare. The prognosis is generally more favorable for this condition than for diffuse malignant mesothelioma. An elderly woman recently complained of abdominal pain, fever, and weight loss. She had no history of asbestos exposure. Her serum CEA level was elevated. Plain CT revealed a mass under the left diaphragm, with liquefaction and necrosis. A contrast-enhanced scan showed circular enhancement of the mass. A subsequent biopsy of the mass revealed a poorly differentiated...
Thu Jun 25, 2020 03:00
Schwannoma is a slow-growing benign tumor, which originates from Schwann cells and is usually asymptomatic. The most common sites of schwannomas are the head, neck, and extremities. However, a schwannoma located in the liver is extremely rare. Here, we report a 53-year-old woman with a hepatic lesion accidentally found by ultrasound. It was highly suggestive of hepatic cholangiocarcinoma by MRI. 18F-FDG PET/CT could not exclude hepatic malignant tumor due to its high metabolism. Finally, it was confirmed...
Thu Jun 25, 2020 03:00
An 81-year-old woman was admitted with chest tightness and shortness of breath. Chest CT revealed massive pleural effusion on the right side as well as a right paravertebral soft tissue mass at the T8 to T10 level, showing intense enhancement. Her symptoms were successfully relieved by thoracentesis catheter drainage. On PET/CT, the paravertebral lesion demonstrated increased FDG uptake with an SUVmax of 7.5, indicating a suspected diagnosis of malignancy. Eventually, a CT-guided needle biopsy was...
Thu Jun 25, 2020 03:00
Interdigitating dendritic cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating dendritic cell sarcoma in a 30-year-old woman. Received for publication May 5, 2020; revision accepted May 6, 2020. Conflicts of interest and sources of funding: none declared....
Thu Jun 25, 2020 03:00
A 56-year-old man with metastatic castration-resistant prostate cancer was referred for radioligand therapy with 177Lu–prostate-specific membrane antigen. In the third cycle, a posttherapy whole-body scan showed unexpected skeletal and joint uptake apart from his known metastatic lesions. This observation raised suspicion for possible impurity (mainly free lutetium) in the applied radiopharmaceutical product. After contacting the radiopharmaceutical company, we were informed that the radiochemical...
Thu Jun 25, 2020 03:00
The whole-body absolute quantification of 177Lu-DOTATATE therapy was achieved using a high-speed 360° CZT SPECT/CT system. Twelve high-resolution swelling detectors may be positioned close to patients, providing a high-count sensitivity that is particularly advantageous for the low-count rate conditions of 177Lu imaging. After initially validating 177Lu quantification on phantom, serial whole-body SPECT/CT acquisitions of only 20 minutes were obtained for a 70-year-old woman treated by 177Lu-DOTATATE...
Thu Jun 25, 2020 03:00
A 64-year-old man with recently diagnosed prostate adenocarcinoma with a total prostate-specific antigen level of 3.32 ng/mL and Gleason score 4 (3 + 4) was referred for 68Ga–prostate-specific membrane antigen PET/CT scan for pretreatment staging. Prostate-specific membrane antigen–avid lesion was noted in the right lobe of the prostate gland, corresponding to the known primary lesion. Note was made of another prostate-specific membrane antigen–avid lesion in the right parietal lobe of brain, likely...
Thu Jun 25, 2020 03:00
Purpose Advanced inoperable/metastatic neuroendocrine tumors (NETs) pose a therapeutic challenge with limited treatment options. Peptide receptor radionuclide therapy (PRRT), being specific in targeting the somatostatin receptors, is a promising and viable option in this setting. In this study, we intended to evaluate the role of PRRT as the first-line systemic therapy in advanced inoperable/metastatic NETs. Methods Data of consecutive patients of advanced inoperable/metastatic NETs...
Thu Jun 25, 2020 03:00
Cardiac sarcoidosis (CS) has a poor prognosis related to life-threating arrhythmias and heart failure. Treatment includes anti-inflammatory therapies and implantable pacemaker and/or cardioverter defibrillator. The presence of cardiac devices and physiologic myocardial glucose uptake are major limitations of both cardiac magnetic resonance and 18F-FDG PET/CT, reducing their diagnostic value. Somatostatin-based PET/CT has been proposed to detect active CS. Contrarily to 18F-FDG uptake, which reflects...
Thu Jun 25, 2020 03:00
Fibrodysplasia ossificans progressiva is a rare debilitating, connective tissue disease characterized by progressive extraosseous ossification with abnormal great toes. Clinical (hallux valgus), radiological, and classical bone scan findings help to reach diagnosis and prevent patient from unnecessary surgical interventions for fibrodysplasia ossificans progressiva lesions and radiotherapy cycles. Here we present a case where a child presented with multiple swellings over the body and hallux valgus,...
Thu Jun 25, 2020 03:00
Primary sacral lymphoma is an unusual bone malignant tumor that poses a diagnostic challenge. Herein, we report a rare case of primary sacral lymphoma, which was initially assessed as suspicious bone metastasis. The subsequent histology and immunohistochemistry of the sacral biopsy confirmed the diagnosis of diffuse large B-cell lymphoma. Received for publication March 26, 2020; revision accepted May 24, 2020. Conflicts of interest and sources of funding: none declared. T.X. and W.F....
Thu Jun 25, 2020 03:00
A 31-year-old man developed diarrhea, fatigue, and intermittent fever for 2 weeks. The past few days he had experienced increasing dyspnea and dry cough. Ambulatory reverse transcriptase–polymerase chain reaction testing was positive for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Because of elevated D-dimer (1.5 mg/L), a lung scintigraphy (V/Q scan) was performed as SPECT/CT. Ventilation SPECT showed reduced ventilation with central nuclide deposition, whereas perfusion SPECT was...
Thu Jun 25, 2020 03:00
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