Related Articles The Medially-Invasive Cholesteatoma: An Aggressive Subtype of a Common Pathology. Ann Otol Rhinol Laryngol. 2020 Jun 30;:3489420937731 Authors: Casazza G, Carlson ML, Shelton C, Gurgel RK Abstract OBJECTIVE: Describe the outcomes of treatment for patients with cholesteatomas that are medially invasive to the otic capsule, petrous apex, and/or skull base. STUDY DESIGN: Retrospective case series. SETTING:...
Wed Jul 01, 2020 13:17
Related Articles Effect of Low-Pressure Drainage Suction on Pharyngocutaneous Fistula After Total Laryngectomy. Ann Otol Rhinol Laryngol. 2020 Jun 29;:3489420934506 Authors: Maleki Delarestaghi M, Ahmadi A, Dehghani Firouzabadi F, Roomiani M, Dehghani Firouzabadi M, Faham Z Abstract OBJECTIVE: Pharyngocutaneous fistula (PCF) is one of the most severe multifactorial complications following laryngectomy. The current study aimed at determining...
Wed Jul 01, 2020 13:17
Related Articles Allergic Fungal Sinusitis Imitating an Aggressive Skull Base Lesion in the Setting of Pembrolizumab Immunotherapy. Ann Otol Rhinol Laryngol. 2020 Jun 29;:3489420937728 Authors: Krane NA, Beswick DM, Sauer D, Detwiller K, Shindo M Abstract OBJECTIVES: We report a case of acutely worsening allergic fungal sinusitis in a patient receiving immunotherapy with pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor....
Wed Jul 01, 2020 13:17
Related Articles Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders. Front Neurosci. 2020;14:609 Authors: O'Connell EM, Lohoff FW Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in familial hypercholesterolemia. Although PCSK9 was first...
Wed Jul 01, 2020 13:13
Related Articles Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study. Front Neurosci. 2020;14:596 Authors: Fuchshuber J, Unterrainer HF, Hiebler-Ragger M, Koschutnig K, Papousek I, Weiss EM, Fink A Abstract An increasing amount of evidence indicates the significance of attachment in the etiology of poly-drug use disorder (PUD). The aim of this study was to investigate associations between PUD and adult...
Wed Jul 01, 2020 13:13
Related Articles Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value. Front Neurosci. 2020;14:579 Authors: Loeffler T, Schilcher I, Flunkert S, Hutter-Paier B Abstract Neurofilament-light chain (NF-L) is a well-known clinical biomarker of many neurodegenerative diseases. By analyzing amyotrophic lateral sclerosis (ALS) patients cerebrospinal fluid (CSF) or plasma, progression of NF-L levels...
Wed Jul 01, 2020 13:13
Related Articles HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy. Front Neurosci. 2020;14:574 Authors: Hampton DW, Amor S, Story D, Torvell M, Bsibsi M, van Noort JM, Chandran S Abstract Progressive neuronal death during tauopathies is associated with aggregation of modified, truncated or mutant forms of tau protein. Such aggregates are neurotoxic, promote spreading of tau aggregation, and trigger release of...
Wed Jul 01, 2020 13:13
Related Articles Editorial: Bridging Gaps Between Sex and Gender in Neurosciences. Front Neurosci. 2020;14:561 Authors: Duchesne A, Pletzer B, Pavlova MA, Lai MC, Einstein G PMID: 32595445 [PubMed]
Wed Jul 01, 2020 13:13
Related Articles The Influences of Brand Awareness on Consumers' Cognitive Process: An Event-Related Potentials Study. Front Neurosci. 2020;14:549 Authors: Zhang X Abstract Brand awareness plays an important role in most aspects of marketing. However, consumers' cognitive process of brand awareness, which plays an important role in purchase decision or product usage experiences, is still unclear in the brain. Using event-related potentials...
Wed Jul 01, 2020 13:13
Related Articles TDP-43 Is Efficiently Transferred Between Neuron-Like Cells in a Manner Enhanced by Preservation of Its N-Terminus but Independent of Extracellular Vesicles. Front Neurosci. 2020;14:540 Authors: Sackmann C, Sackmann V, Hallbeck M Abstract The misfolding of transactive response DNA-binding protein (TDP-43) is a major contributor to the pathogenesis of TDP-43 proteinopathies, including amyotrophic lateral sclerosis and frontotemporal...
Wed Jul 01, 2020 13:13
Related Articles Hemoglobin Concentration May Affect the Effect of Atorvastin on Chronic Subdural Hematoma After Burr-Hole Drainage at High Altitude. Front Neurosci. 2020;14:503 Authors: Wei L, Lin C, Zhong M, Zhang J, Zhu G Abstract Objective: Chronic subdural hematoma (CSDH) is a common disease. Atorvastatin calcium can increase CSDH absorption. However, whether atorvastatin can increase hematoma absorption and reduce recurrence at high altitudes...
Wed Jul 01, 2020 13:13
Related Articles Seizure Classification From EEG Signals Using an Online Selective Transfer TSK Fuzzy Classifier With Joint Distribution Adaption and Manifold Regularization. Front Neurosci. 2020;14:496 Authors: Zhang Y, Zhou Z, Bai H, Liu W, Wang L Abstract To recognize abnormal electroencephalogram (EEG) signals for epileptics, in this study, we proposed an online selective transfer TSK fuzzy classifier underlying joint distribution adaption...
Wed Jul 01, 2020 13:13
Related Articles The Profiles of Non-stationarity and Non-linearity in the Time Series of Resting-State Brain Networks. Front Neurosci. 2020;14:493 Authors: Guan S, Jiang R, Bian H, Yuan J, Xu P, Meng C, Biswal B Abstract The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state...
Wed Jul 01, 2020 13:13
Related Articles Suitability of Thrombolysis for Patients With Acute Ischemic Stroke Complicated With Trousseau Syndrome. Front Neurosci. 2020;14:481 Authors: Chen Y, Zhang C, Wang X, Han L, Zhu S, Liu Y, Wang R, Geng Z, Ma C, Dong R Abstract Intravenous thrombolysis (IVT) improves functional outcome after acute ischemic stroke (AIS) and is the standard first-line treatment; however, it is associated with many complications, including cerebral...
Wed Jul 01, 2020 13:13
Related Articles Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets. Front Neurosci. 2020;14:479 Authors: Wang T, Tang Z, Yu X, Gao Y, Guan F, Li C, Huang S, Zheng J, Zeng P Abstract Objective: Prior studies have shown that there is an inverse association between birth weight and stroke in adulthood; however, whether such association is causal remains yet known and those studies...
Wed Jul 01, 2020 13:13
Related Articles Biologically Relevant Dynamical Behaviors Realized in an Ultra-Compact Neuron Model. Front Neurosci. 2020;14:421 Authors: Stoliar P, Schneegans O, Rozenberg MJ Abstract We demonstrate a variety of biologically relevant dynamical behaviors building on a recently introduced ultra-compact neuron (UCN) model. We provide the detailed circuits which all share a common basic block that realizes the leaky-integrate-and-fire (LIF) spiking...
Wed Jul 01, 2020 13:13
Related Articles Computer-Assisted Quantitative Analysis of Drug-Induced Sleep Endoscopy for Obstructive Sleep Apnea/Hypopnea Syndrome. Otolaryngol Head Neck Surg. 2020 Jun 30;:194599820933206 Authors: Lai CC, Lin PW, Lin HC, Friedman M, Salapatas AM, Chen JP, Chang HW, Juang SE, Wu SC, Lin MC Abstract OBJECTIVES: To use computer-assisted quantitative measurements of upper airway changes during drug-induced sleep endoscopy (DISE) and to correlate...
Wed Jul 01, 2020 13:14
Related Articles [Clinical profile of patients with obstructive sleep apnea syndrome in a cardiology hospital]. Ter Arkh. 2020 May 19;92(4):9-16 Authors: Elfimova EM, Mikhailova OO, Khachatryan NT, Litvin AY, Сhazova IE Abstract RELEVANCE: Obstructive sleep apnea syndrome (OSAS) is an important medical and social problem due to its high prevalence and impact on quality of life. The relationship between OSAS and cardiovascular pathology has been...
Wed Jul 01, 2020 13:14
Related Articles Effect of endoscopic endonasal skull base surgery on snoring. Laryngoscope Investig Otolaryngol. 2020 Jun;5(3):344-347 Authors: Kim DH, Lee MH, Lee J, Kim SW Abstract Background: As the number of endoscopic skull base surgeries has increased, postoperative changes in quality of life require attention, including evaluation of whether snoring symptoms change. Objective: To investigate the effect of endoscopic endonasal...
Wed Jul 01, 2020 13:14
Related Articles An alternative molecular approach for rapid and specific detection of clinically relevant bacteria causing prosthetic joint infections with bacteriophage K. New Microbiol. 2020 Jun 29;43(3) Authors: Šuster K, Podgornik A, Cör A Abstract Prosthetic joint infections (PJI) represent the most serious cause of prosthetic joint loosening, with high impact on patient life and health economics. Although not entirely reliable, the...
Wed Jul 01, 2020 13:12
Related Articles In Vitro Activity of Ceftazidime/Avibactam Alone and in Combination With Fosfomycin and Carbapenems Against KPC-producing Klebsiella Pneumoniae. New Microbiol. 2020 Jun 29;43(3) Authors: Romanelli F, De Robertis A, Carone G, Dalfino L, Stufano M, Del Prete R, Mosca A Abstract KPC-producing Klebsiella pneumonia (KPC-Kp) represents a major therapeutic challenge in critically ill patients. Ceftazidime-avibactam (CAZ-AVI) is...
Wed Jul 01, 2020 13:12
Related Articles Epidemiology and antimicrobial susceptibility of Staphylococcus lugdunensis in a Greek tertiary-care hospital. New Microbiol. 2020 Jun 29;43(3) Authors: Kachrimanidou M, Malliou P, Meletis G, Netsika F, Mavrovouniotis I, Protonotariou E, Skoura L Abstract Staphylococcus lugdunensis is considered more pathogenic than other coagulase-negative Staphylococci (CoNS), with its virulence resembling that of Staphylococcus aureus....
Wed Jul 01, 2020 13:12
Related Articles Tetracycline resistance in Moraxella catarrhalis clinical strains isolated in Poland. New Microbiol. 2020 Jun 29;43(3) Authors: Król-Turmińska K, Olender A, Bogut A Abstract Moraxella catarrhalis is considered an important, exclusively human respiratory tract pathogen which, along with Streptococcus pneumoniae and Haemophilus influenzae, is classified as one of the most frequent bacterial etiological factors causing upper...
Wed Jul 01, 2020 13:12
Related Articles Estimation of lifetime cumulative mortality risk of lung cancer by smoking status in Japan. Jpn J Clin Oncol. 2020 Jun 30;: Authors: Hori M, Saito E, Katanoda K, Tsugane S Abstract The main objective of this study was to estimate the cumulative mortality risk for lung cancer according to smoking status and exposure to secondhand smoke (SHS) in Japan. We applied a life-table method to estimate the cumulative risk. Estimated lifetime...
Wed Jul 01, 2020 13:10
Related Articles Development and validation of a Super learner-based model for predicting survival in Chinese Han patients with resected colorectal cancer. Jpn J Clin Oncol. 2020 Jun 29;: Authors: Li J, Gu J, Lu Y, Wang X, Si S, Xue F Abstract OBJECTIVE: Improved prognostic prediction for patients with colorectal cancer stays an important challenge. This study aimed to develop an effective prognostic model for predicting survival in resected...
Wed Jul 01, 2020 13:10
Related Articles Chondroblastoma in the Sphenoid Sinus. Ear Nose Throat J. 2020 Jun 30;:145561320934225 Authors: Long L, Li Z, Tang Y PMID: 32603219 [PubMed - as supplied by publisher]
Wed Jul 01, 2020 13:10
Related Articles Isoniazid-Resistant Tuberculosis of the Parotid Gland Masquerading as a Benign Neoplasm. Ear Nose Throat J. 2020 Jun 30;:145561320938159 Authors: Lee S, Chirch LM, Sosa L, Wu Q, Falcone TE PMID: 32603218 [PubMed - as supplied by publisher]
Wed Jul 01, 2020 13:10
Related Articles The Use of Lasers in Stapes Surgery. Ear Nose Throat J. 2020 Jun 30;:145561320937828 Authors: Srivastava R, Cho W, Fergie N Abstract OBJECTIVES: Otosclerosis is a disease process that usually starts around the oval window, causing fixation of the stapes, resulting in conductive hearing loss. Treatment of the conductive hearing loss caused by otosclerosis consists of either rehabilitation with hearing aids or performing...
Wed Jul 01, 2020 13:10
Related Articles The Significance of Staging in the Treatment of Congenital Cholesteatoma in Children. Ear Nose Throat J. 2020 Jun 30;:145561320933965 Authors: Hao J, Chen M, Liu B, Yang Y, Liu W, Zhang J, Ni X Abstract OBJECTIVES: To analyze the clinical characteristics of congenital cholesteatoma (CC), to explore the risk factors related to recurrence of the disease, and to clarify the importance of staging for treatment. METHODS:...
Wed Jul 01, 2020 13:10
Related Articles Angioleiomyoma of the Larynx: A Case Report and Literature Review. Ear Nose Throat J. 2020 Jun 30;:145561320934930 Authors: Perardi F, Abbate G, Iannuzzelli LR, Contini R, De Munari M, Sciuto FG, Leutner M, Scotti A Abstract Angioleiomyoma is a benign smooth muscle and vessel tumor; laryngeal localization is extremely rare with only 24 cases described in the literature; moreover, it should be considered in the differential...
Wed Jul 01, 2020 13:10
Related Articles Diffusion MR Imaging in the Head and Neck: Principles and Applications. Neuroimaging Clin N Am. 2020 Aug;30(3):261-282 Authors: Norris CD, Quick SE, Parker JG, Koontz NA Abstract Diffusion imaging is a functional MR imaging tool that creates tissue contrast representative of the random, microscopic translational motion of water molecules within human body tissues. Long considered a cornerstone MR imaging sequence for brain imaging,...
Wed Jul 01, 2020 13:03
Related Articles 25I-NBOMe, a phenethylamine derivative, induces adverse cardiovascular effects in rodents: possible involvement of p21 (CDC42/RAC)-activated kinase 1. Drug Chem Toxicol. 2020 Jun 29;:1-9 Authors: Yoon KS, Gu SM, Cha HJ, Kim YH, Yun J, Lee JM Abstract Abuse of new psychoactive substances is an emerging social problem. Several phenethylamines are internationally controlled substances as they are likely to be abused and have adverse...
Wed Jul 01, 2020 13:03
Related Articles Dexamethasone increases renal free fatty acids and xanthine oxidase activity in female rats: could there be any gestational impact? Drug Chem Toxicol. 2020 Jun 29;:1-12 Authors: Badmus OO, Sabinari IW, Olatunji LA Abstract Dexamethasone (DEX) is used for various conditions in female and even during pregnancy. We tested the hypothesis that DEX exposure in female rats would lead to renal free fatty acid (FFA) accumulation with...
Wed Jul 01, 2020 13:03
Related Articles Placental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants. Drug Chem Toxicol. 2020 Jun 29;:1-10 Authors: Agarwal P, Anand M, Chakraborty P, Singh L, Masih J, Taneja A Abstract As an alarming group of pollutants, polycyclic aromatic hydrocarbons (PAHs) gather much public health concern not only because of their carcinogenic or co-carcinogenic risk but also by interfering with...
Wed Jul 01, 2020 13:03
Related Articles Comprehensive investigation into the role of ubiquitin conjugating enzyme E2S (UBE2S) in melanoma development. J Invest Dermatol. 2020 Jun 27;: Authors: Wang P, Li Y, Ma Y, Zhang X, Li Z, Yu W, Zhu M, Wang J, Xu Y, Xu A Abstract Ubiquitin conjugating enzyme E2S (UBE2S) is involved in protein degradation and signal transduction, but its function in the development of melanoma is unclear. We focused on the role of UBE2S on...
Wed Jul 01, 2020 13:02
Related Articles Modulation of MicroRNAs by Euphorbia microsciadia Boiss in MDA-MB-231: New Possibilities in Breast Cancer Therapy. Recent Pat Anticancer Drug Discov. 2020 Jun 29;: Authors: Mahmoudian-Sani MR, Asadi-Samani M Abstract BACKGROUND: A large number of Euphorbia species have been evaluated for anticancer effects; however, their anticancer mechanisms have not been established up to now. OBJECTIVE: The present study aimed...
Wed Jul 01, 2020 13:02
Related Articles Pharmacological disruption of the Notch transcription factor complex. Proc Natl Acad Sci U S A. 2020 Jun 29;: Authors: Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke F Abstract Notch pathway signaling is implicated in several human cancers....
Wed Jul 01, 2020 13:02
Related Articles Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia. BMC Cancer. 2020 Jun 29;20(1):603 Authors: Kuo IM, Lee JJ, Wang YS, Chiang HC, Huang CC, Hsieh PJ, Han W, Ke CH, Liao ATC, Lin CS Abstract BACKGROUND: Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in cancer treatment. mEHT has demonstrated the...
Wed Jul 01, 2020 13:02
Related Articles Tyr-nitration in maize CDKA;1 results in lower affinity for ATP binding. Biochim Biophys Acta Proteins Proteom. 2020 Jun 26;:140479 Authors: Méndez AAE, Mangialavori IC, Cabrera AV, Benavides MP, Vázquez-Ramos JM, Gallego SM Abstract Cyclin-dependent kinase A (CDKA) is a key component for cell cycle progression. The catalytic kinase activity depends on the protein's ability to form an active complex with cyclins and on...
Wed Jul 01, 2020 13:02
Related Articles Screening and Identification of Key Biomarkers in Inflammatory Breast Cancer Through Integrated Bioinformatic Analyses. Genet Test Mol Biomarkers. 2020 Jun 27;: Authors: Wu J, Lv Q, Huang H, Zhu M, Meng D Abstract Background: Inflammatory breast cancer (IBC) is a rare type of breast cancer with poor prognoses, moreover its pathogenesis is not entirely clear. The aim of this study was to identify key genes of IBC, which...
Wed Jul 01, 2020 13:02
Related Articles Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Prolif. 2020 Jun 29;:e12869 Authors: Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, Han L, Xin X, Wang H, Lin D, Peng F, Yu F, Zheng C, Shen C Abstract OBJECTIVES: Cryptococcus heimaeyensis S20 is found in Antarctica and can produce exopolysaccharides (CHEPS). Here,...
Wed Jul 01, 2020 13:02
Related Articles Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A. ACS Omega. 2020 Jun 23;5(24):14586-14596 Authors: Lee MM, Chan BD, Wong WY, Leung TW, Qu Z, Huang J, Zhu L, Lee CS, Chen S, Tai WC Abstract Cancer is the second leading cause of death globally, responsible for an estimated 9.6 million deaths in 2018, and this burden continues to increase. Therefore, there is a clear and urgent...
Wed Jul 01, 2020 13:02
Related Articles Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evid Based Complement Alternat Med. 2020;2020:5867064 Authors: Hsu PC, Cheng CF, Hsieh PC, Chen YH, Kuo CY, Sytwu HK Abstract Background: Oral cancer belongs to the class of head and neck cancers and can be life threatening if not diagnosed and treated early. Activation of cell death via apoptosis or reactive oxygen...
Wed Jul 01, 2020 13:02
Related Articles Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer. Med Sci Monit. 2020 Jun 17;26:e922346 Authors: Zhu J, Jin L, Zhang A, Gao P, Dai G, Xu M, Xu L, Yang D Abstract BACKGROUND This study aimed to perform coexpression analysis of the EZH2 gene using The Cancer Genome Atlas...
Wed Jul 01, 2020 13:02
Related Articles Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-κB pathway in collagen-induced arthritis rats. Mol Cell Biochem. 2020 Jun 27;: Authors: Wang Q, Xu B, Fan K, Wu J, Wang T Abstract Dexamethasone (Dex) exhibits broad-spectrum anti-inflammatory effects in chronic destructive rheumatoid arthritis. We present in vivo and in vitro evidence supporting the preventive effects and underlying mechanisms...
Wed Jul 01, 2020 13:02
Related Articles CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT/mTOR pathway. Clin Transl Oncol. 2020 Jun 27;: Authors: Luan Y, Zhang W, Xie J, Mao J Abstract PURPOSE: The current study aims to explore the effects of CDKN2A on cell proliferation and cycle, and investigate the underlying mechanisms. METHODS: Expression of CDKN2A in cervical cancer cell lines was evaluated by real-time...
Wed Jul 01, 2020 13:02
Related Articles Metabolic Regulation of Human Pluripotent Stem Cell-Derived Cardiomyocyte Maturation. Curr Cardiol Rep. 2020 Jun 27;22(8):73 Authors: Batho CAP, Mills RJ, Hudson JE Abstract PURPOSE OF REVIEW: This review summarizes the important role that metabolism plays in driving maturation of human pluripotent stem cell-derived cardiomyocytes. RECENT FINDINGS: Human pluripotent stem cell-derived cardiomyocytes provide a model...
Wed Jul 01, 2020 13:02
Related Articles Neuroprotective mechanisms of DNA methyltransferase in a mouse hippocampal neuronal cell line after hypoxic preconditioning. Neural Regen Res. 2020 Dec;15(12):2362-2368 Authors: Liu N, Zhang XL, Jiang SY, Shi JH, Cui JH, Liu XL, Han LH, Gong KR, Yan SC, Xie W, Zhang CY, Shao G Abstract Hypoxic preconditioning has been shown to improve hypoxic tolerance in mice, accompanied by the downregulation of DNA methyltransferases...
Wed Jul 01, 2020 13:02
Related Articles Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells. Anticancer Agents Med Chem. 2020 Jun 27;: Authors: An X, Wei Z, Ran B, Tian H, Gu H, Liu Y, Cui H, Zhu S Abstract BACKGROUND: Gastric cancer, a common malignant tumour worldwide, has a relatively poor prognosis and is a serious threat to human health. Histone...
Wed Jul 01, 2020 13:02
Related Articles Metabolic consequences of immune checkpoint inhibitors: A new challenge in clinical practice. Crit Rev Oncol Hematol. 2020 Jul;151:102979 Authors: Parthymos I, Liamis G, Dounousi E, Pentheroudakis G, Mauri D, Zarkavelis G, Florentin M Abstract Treatment of oncologic patients has progressed greatly the last few years with the development of immune checkpoint inhibitors (ICPIs). These drugs are associated with the immune system...
Wed Jul 01, 2020 13:02
Related Articles Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resistance. J Med Chem. 2020 01 09;63(1):186-204 Authors: Liu Z, Wang M, Wang H, Fang L, Gou S Abstract Inhibiting/disturbing the RAS/RAF pathway may benefit the treatment of cancer and overcome the resistance. Utilizing such a pathway as the target, nine...
Wed Jul 01, 2020 13:02
Related Articles Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. Cancer Lett. 2020 01 28;469:195-206 Authors: Nan X, Wang J, Cheng H, Yin Z, Sheng J, Qiu B, Lau CC, Yustein JT, Zhao H, Wong STC Abstract Ewing sarcoma (EwS) is an aggressive pediatric tumor treated with intensive cytotoxic chemotherapies. Overall survival for metastatic...
Wed Jul 01, 2020 13:02
Related Articles Novel functions of the primary cilium in bone disease and cancer. Cytoskeleton (Hoboken). 2019 03;76(3):233-242 Authors: Shi W, Ma Z, Zhang G, Wang C, Jiao Z Abstract The primary cilium, a sensory organelle that emanates from the cell surface of most mammalian cell types during growth arrest, has attracted the attention of many researchers over the past decade. Recently, a large number of new findings have assigned novel functions...
Wed Jul 01, 2020 13:02
Related Articles Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019 04 30;12(579): Authors: Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM Abstract The role of the mitochondrial Ca2+ uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU...
Wed Jul 01, 2020 13:02
Related Articles Therapeutic potential of PLK1 inhibition in triple-negative breast cancer. Lab Invest. 2019 09;99(9):1275-1286 Authors: Ueda A, Oikawa K, Fujita K, Ishikawa A, Sato E, Ishikawa T, Kuroda M, Kanekura K Abstract Triple negative breast cancer (TNBC) is responsible for significant number of breast cancer-associated deaths because of lacking of successful molecular-targeted therapy. To explore a therapeutic target for TNBC, we performed...
Wed Jul 01, 2020 13:02
Related Articles Trends in Checkpoint Inhibitor Therapy for Advanced Urothelial Cell Carcinoma at the End of Life: Insights from Real-World Practice. Oncologist. 2019 06;24(6):e397-e399 Authors: Parikh RB, Galsky MD, Gyawali B, Riaz F, Kaufmann TL, Cohen AB, Adamson BJS, Gross CP, Meropol NJ, Mamtani R Abstract Several immune checkpoint inhibitor therapies (CPIs) have been approved to treat metastatic urothelial cell carcinoma (mUC). Because...
Wed Jul 01, 2020 13:02
Related Articles Knockdown of KLF5 promotes cisplatin-induced cell apoptosis via regulating DNA damage checkpoint proteins in non-small cell lung cancer. Thorac Cancer. 2019 05;10(5):1069-1077 Authors: Zhang H, Shao F, Guo W, Gao Y, He J Abstract BACKGROUND: Previous research has revealed that Krüppel-like factor 5 (KLF5) may affect DNA damage repair pathways; however, the associated molecular mechanisms are unclear. METHODS: The...
Wed Jul 01, 2020 13:02
Related Articles TGF-β Family Signaling Pathways in Cellular Dormancy. Trends Cancer. 2019 01;5(1):66-78 Authors: Prunier C, Baker D, Ten Dijke P, Ritsma L Abstract Individual cancer cells can switch, reversibly, to a non-proliferative dormant state, a process characterized by two principal stages: (i) establishment and maintenance, and (ii) the breaking of dormancy. This phenomenon is of clinical importance because dormant cells resist chemotherapy,...
Wed Jul 01, 2020 13:02
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