Abstract Cryptococcosis is a potentially fatal fungal disease which has aggrandized with the emergence of AIDS and antifungal resistance. The currently used antifungals lack the broad-spectrum activity and result in several toxicities during long treatment regimens. Thus, the present study aims to evaluate the antifungal activity of cinnamaldehyde against Cryptococcus neoformans var. grubii, the etiological agent of the disease. Quantitative and qualitative in vitro fungal susceptibilities...
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Abstract Rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) is essential for proper initial antibiotic therapy and timely set up of hygienic measures. Recently, detection of MRSA using MALDI-TOF mass spectrometer mediated by the peptide—phenol-soluble modulin (PSM-mec)—linked to the class A mec gene complex present in SCCmec cassettes types II, III, and VIII of MRSA strains, has been commercially available. We present here a multicentre study on MALDI-TOF...
03:00
Glomus tumors (GTs), together with myofibroma (MF), myopericytoma (MP), and angioleiomyoma (AL) are classified as members of the perivascular myoid family of tumors. The reported genetic abnormalities across these neoplasms is dissimilar, arguing against a pathogenetically unified family; half of the GT showing NOTCH-gene fusions and a smaller subset BRAFV600E mutations, while PDGFRB mutations are noted in a subset of MF and MP. This study aimed to investigate the prevalence and specificity of NOTCH-gene...
Fri Jun 26, 2020 03:00
Individuals with acquired cystic kidney disease (ACKD) in the setting of end-stage renal disease (ESRD) have a high risk of developing renal cell carcinoma (RCC). ACKD-RCC is considered a distinct renal neoplasm in the International Society of Urologic Pathologists (ISUP)-World Health Organization (WHO) classification of kidney tumors which may behave aggressively. Since its original description, there have been multiple case reports and series published; however, the pathogenesis of this neoplasm...
Fri Jun 26, 2020 03:00
Breslow thickness (BT) is the cornerstone of malignant melanoma staging. However, to our knowledge no-one has ever assessed the horizontal width of invasion, measured microscopically, as a prognostic feature. This was investigated as a prognostic feature in this study. A retrospective cohort of 1329 melanoma cases was collected from patients presenting to a UK teaching hospital from January 1, 2004, to December 31, 2014. The main outcome was overall survival (OS). We found that width was associated...
Fri Jun 26, 2020 03:00
Some recent reports suggested that many Sertoli cell tumors, not otherwise specified (SCTs-NOS) of the testis were analogs of the solid pseudopapillary neoplasm (SPN) of the pancreas. One of the most relied on pieces of information for this assertion was the shared occurrence in both neoplasms of exon 3 mutations of the CTNNB1 gene, which was reflected by nuclear β-catenin expression. We, therefore, compared the morphologic and immunohistochemical features of 18 SCTs-NOS with strong, diffuse nuclear...
Fri Jun 26, 2020 03:00
Mixed endometrial carcinomas are defined as a combination of 2 or more distinct histologic subtypes, one of which must be a type II tumor comprising at least 5% of the tumor volume. The oncogenesis of these tumors remains unclear, particularly in light of the increasingly appreciated morphologic overlap among subtypes, as well as evolving molecular data. We evaluated 8 cases of mixed endometrial carcinoma, including 4 endometrioid (EC)/serous (SC), 1 SC/clear cell (CC), and 3 EC/CC cases, to study...
Fri Jun 26, 2020 03:00
Hirschsprung disease (HD) is a congenital disorder of the enteric nervous system that occurs in ∼1 in 5000 live births. It is characterized by the absence of ganglionic cells (GCs) in the distal intestine. The diagnosis relies on the thorough analysis of a rectal suction biopsy (RSB), which must show a complete absence of GCs after careful examination of at least 100 serial sections. Such a negative characteristic explains the difficulty of this diagnosis. Moreover, GCs may be immature in very young...
Fri Jun 26, 2020 03:00
Conditions: Recurrent Nasopharyngeal Carcinoma; Chemotherapy; Radiotherapy; PD-1 TreatmentInterventions: Drug: Toripalimab plus concurrent chemo-radiotherapy; Drug: Concurrent chemo-radiotherapySponsors: Sun Yat-sen University; Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Zhongshan People's Hospital, Guangdong, China; Yuebei People's Hospital; Wuzhou Red Cross Hospital; Fifth Affiliated Hospital, Sun Yat-Sen UniversityNot yet recruiting
Wed Jul 01, 2020 16:22
Condition: Familial Adenomatous PolyposisIntervention: Drug: Azithromycin TabletsSponsors: Tel-Aviv Sourasky Medical Center; Tel Aviv UniversityNot yet recruiting
Wed Jul 01, 2020 16:22
Conditions: Advanced Head and Neck Squamous Cell Carcinoma; Recurrent Head and Neck Squamous Cell Carcinoma; Metastatic Head-and-neck Squamous-cell CarcinomaInterventions: Drug: Pembrolizumab (immunotherapy); Radiation: Quad-shot palliative radiotherapySponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)Not yet recruiting
Wed Jul 01, 2020 16:22
Condition: Head and Neck CancerIntervention: Device: tissue retractorsSponsor: University Hospital HeidelbergNot yet recruiting
Wed Jul 01, 2020 16:22
Conditions: Nasopharyngeal Carcinoma; Chemotherapy; Radiotherapy; PD-1 TherapyInterventions: Drug: Camrelizumab plus chemo-radiotherapy; Drug: Chemo-radiotherapy aloneSponsors: Sun Yat-sen University; Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Zhongshan People's Hospital, Guangdong, China; Yuebei People's Hospital; Wuzhou Red Cross Hospital; Fifth Affiliated Hospital, Sun Yat-Sen UniversityNot yet recruiting
Wed Jul 01, 2020 16:22
Publication date: Available online 30 June 2020Source: Medical Image AnalysisAuthor(s): Florian Dubost, Hieab Adams, Pinar Yilmaz, Gerda Bortsova, Gijs van Tulder, M.Arfan Ikram, Wiro Niessen, Meike W. Vernooij, Marleen de Bruijne
Wed Jul 01, 2020 16:17
Publication date: Available online 1 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Joshua B. Simmons, Robert S. Turner, Jonathan C. Horton
Wed Jul 01, 2020 16:11
Publication date: Available online 30 June 2020Source: Journal of Neuroscience MethodsAuthor(s): H Kloefkorn, LM Aiani, A Lakhani, S Nagesh, A Moss, W Goolsby, JM Rehg, NP Pedersen, S Hochman
Wed Jul 01, 2020 16:11
Publication date: Available online 30 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Lars Stumpp, Hugo Smets, Simone Vespa, Joaquin Cury, Pascal Doguet, Jean Delbeke, Emmanuel Hermans, Christian Sevcencu, Thomas N. Nielsen, Antoine Nonclerq, Riem El Tahry
Wed Jul 01, 2020 16:11
Publication date: Available online 30 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Rongrong Fu, Mengmeng Han, Yongsheng Tian, Peiming Shi
Wed Jul 01, 2020 16:11
Publication date: Available online 30 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Kyung Sik Yi, Chi-Hoon Choi, Cheolkyu Jung, Youngjeon Lee, Chang-Yeop Jeon, Hyun-Gu Yeo, Yujin Ahn, Jinwoo Hwang, Hong Jun Lee, Janggeun Cho, Bitnarae Kwak, Kyung A Kwak, Sang-Rae Lee, Sang-Hoon Cha
Wed Jul 01, 2020 16:11
Related Articles Sphenoid Sinus Involvement in Chronic Rhinosinusitis Without Polyps. Allergy Rhinol (Providence). 2020 Jan-Dec;11:2152656720934472 Authors: Sumaily I, Alarifi I, Alahmari A, Aloulah M, Alsaleh S Abstract Background: Chronic rhinosinusitis (CRS) is a common chronic disease. It has 2 main clinical subtypes: CRS with nasal polyposis (CRSwNP) and without nasal polyps (CRSsNP). The sphenoid sinus appears to be less frequently involved...
Wed Jul 01, 2020 16:10
Publication date: Available online 30 June 2020Source: Gait & PostureAuthor(s): Makoto Ayabe, Hideaki Kumahara
Wed Jul 01, 2020 16:10
Related Articles Contributions of Auditory and Somatosensory Feedback to Vocal Motor Control. J Speech Lang Hear Res. 2020 Jun 30;:1-15 Authors: Smith DJ, Stepp C, Guenther FH, Kearney E Abstract Purpose To better define the contributions of somatosensory and auditory feedback in vocal motor control, a laryngeal perturbation experiment was conducted with and without masking of auditory feedback. Method Eighteen native speakers of English produced...
Wed Jul 01, 2020 16:10
Related Articles Angioleiomyoma of the Larynx: A Case Report and Literature Review. Ear Nose Throat J. 2020 Jun 30;:145561320934930 Authors: Perardi F, Abbate G, Iannuzzelli LR, Contini R, De Munari M, Sciuto FG, Leutner M, Scotti A Abstract Angioleiomyoma is a benign smooth muscle and vessel tumor; laryngeal localization is extremely rare with only 24 cases described in the literature; moreover, it should be considered in the differential diagnosis...
Wed Jul 01, 2020 16:10
Related Articles HCV infection and the risk of head and neck cancer: A meta-analysis. Oral Oncol. 2020 Jun 26;109:104869 Authors: Borsetto D, Fussey J, Fabris L, Bandolin L, Gaudioso P, Phillips V, Polesel J, Boscolo-Rizzo P Abstract Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore,...
Wed Jul 01, 2020 16:10
The effect of partial and total laryngectomy on couples' sexual functions in men with larynx cancer.
Related Articles The effect of partial and total laryngectomy on couples' sexual functions in men with larynx cancer. Eur Arch Otorhinolaryngol. 2020 Jun 28;: Authors: Gür H, Çayan S, Akbay E, Dölek EK, Özcan C, Görür K Abstract PURPOSE: To investigate effect of total or partial laryngectomies with or without adjuvant treatments on couples' sexual functions. METHODS: The study included 39 male patients with laryngeal cancer and their...
Wed Jul 01, 2020 16:10
Related Articles Predictors of chemotherapy and its effects in early stage squamous cell carcinoma of the larynx. Laryngoscope Investig Otolaryngol. 2020 Jun;5(3):445-452 Authors: Jayakrishnan TT, White RJ, Greenberg L, Colonias A, Wegner RE Abstract Background: Squamous cell carcinoma (SCC) of larynx is a common head and neck cancer. For cases that are node negative, the role of definitive concurrent chemoradiation is unclear and not supported...
Wed Jul 01, 2020 16:10
Related Articles Effects of Rheumatoid Arthritis on the Larynx. Iran J Otorhinolaryngol. 2020 May;32(110):147-153 Authors: Dehghan M, Ahmadi A, Yousefghahari B, Kiakojouri K, Gholinia H Abstract Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls. Materials and Methods: This case-control descriptive study was performed...
Wed Jul 01, 2020 16:10
Related Articles Effect of dexmedetomidine sedation on swallowing reflex: A pilot study. J Dent Sci. 2020 Jun;15(2):207-213 Authors: Sanuki T, Mishima G, Ayuse T Abstract Background/purpose: Swallowing reflex depression during dental treatment or oral surgery may cause water to enter the lower respiratory tract, leading to coughing, thus hindering these procedures. Based on the hypothesis that dexmedetomidine (DEX) sedation may depress swallowing...
Wed Jul 01, 2020 16:10
Related Articles POSITIVE EXPRESSION OF NEDD9 IN HEAD AND NECK CANCER IS RELATED TO BETTER SURVIVAL PERIOD. Acta Clin Croat. 2019 Dec;58(4):655-661 Authors: Ledinsky Opačić I, Gršić K, Šitić S, Penavić I, Pastorčić Grgić M, Šarčević B Abstract The aim was to determine immunohistochemical expression of NEDD9 protein in head and neck squamous cell carcinoma (HNSCC) and the possible relation of its expression with primary tumor size (T), regional...
Wed Jul 01, 2020 16:10
Related Articles Carcinoma of the posterior wall of the hypopharynx: surgical treatment with larynx preservation. Braz J Otorhinolaryngol. 2020 Jun 15;: Authors: Bora B, Selin Ü Abstract INTRODUCTION: Posterior pharyngeal wall is the most rare subsite for hypopharyngeal carcinomas. Because of its rarity, there are few studies published in the literature specifically concerning posterior pharyngeal wall carcinoma. OBJECTIVES: To report...
Wed Jul 01, 2020 16:10
Related Articles Non-dystrophic myotonia Chilean cohort with predominance of the SCN4A Gly1306Glu variant. Neuromuscul Disord. 2020 May 19;: Authors: Avila-Smirnow D, Vargas Leal CP, Beytía Reyes MLA, Cortés Zepeda R, Escobar RG, Kleinsteuber Saa K, Lagos Lucero M, Avaria Benapres MLA, Padilla Pérez O, Casar Leturia JC, Mellado Sagredo C, Sternberg D Abstract Non-dystrophic myotonias are a group of rare neuromuscular diseases linked to SCN4A...
Wed Jul 01, 2020 16:10
Related Articles Alternatives for establishing a surgical airway during the COVID-19 pandemic. Rev Col Bras Cir. 2020 Jun 03;47:e20202549 Authors: Lima DS, Ribeiro Junior MF, Vieira-Jr HM, Campos T, Saverio SD Abstract Currently doctors and health professionals are facing a challenging pandemic caused by a new strain called 2019 Novel Coronavirus (COVID-19). Human infection with COVID-19 does not yet have the clinical spectrum fully described,...
Wed Jul 01, 2020 16:10
Related Articles Surgical cricothyroidostomy. Analysis and comparison between teaching and validation models of simulator models. Rev Col Bras Cir. 2020;47:e20202522 Authors: Urdiales AIA, Struck GT, Guetter CR, Yaegashi CH, Temperly KS, Abreu P, Tomasich FS, Campos ACL Abstract OBJECTIVE: to compare the acquisition and retention of knowledge about surgical cricothyroidostomy by the rapid four-step technique (RFST), when taught by expository...
Wed Jul 01, 2020 16:10
Related Articles Cognitive control of orofacial motor and vocal responses in the ventrolateral and dorsomedial human frontal cortex. Proc Natl Acad Sci U S A. 2020 03 03;117(9):4994-5005 Authors: Loh KK, Procyk E, Neveu R, Lamberton F, Hopkins WD, Petrides M, Amiez C Abstract In the primate brain, a set of areas in the ventrolateral frontal (VLF) cortex and the dorsomedial frontal (DMF) cortex appear to control vocalizations. The basic role...
Wed Jul 01, 2020 16:10
Related Articles Subglottic Cryotherapy: A Pilot Study in New Zealand White Rabbits. Otolaryngol Head Neck Surg. 2020 Mar;162(3):326-328 Authors: Cheng J, Everitt J Abstract To describe proof of concept and pilot data for a cryotherapy application in the subglottis in a rabbit airway model. Four New Zealand white rabbits (3 experimental, 1 control) underwent general anesthesia and laryngoscopy and bronchoscopy. Experimental animals had cryotherapy...
Wed Jul 01, 2020 16:10
Related Articles Benign Vocal Fold Lesions in Patients with Chronic Cough. Otolaryngol Head Neck Surg. 2020 Mar;162(3):322-325 Authors: Adessa M, Xiao R, Hull D, Bowen AJ, Milstein CF, Benninger MS, Bryson PC Abstract OBJECTIVE: The objective of this study was to determine the prevalence of benign vocal fold lesions (BVFLs) in patients with chronic cough over a 1-year period. STUDY DESIGN: Case series with chart review. SETTING:...
Wed Jul 01, 2020 16:10
Related Articles Laryngeal Web in the Pediatric Population: Evaluation and Management. Otolaryngol Head Neck Surg. 2020 Feb;162(2):234-240 Authors: Lawlor CM, Dombrowski ND, Nuss RC, Rahbar R, Choi SS Abstract OBJECTIVE: To discuss the presentation, evaluation, and management of pediatric laryngeal web. STUDY DESIGN: Retrospective case series. SETTING: Single tertiary care center. SUBJECTS: All patients with laryngeal...
Wed Jul 01, 2020 16:10
Related Articles Prognostic significance of surgical margins after transoral laser microsurgery for early-stage glottic squamous cell carcinoma. Oral Oncol. 2019 10;97:105-111 Authors: Jumaily M, Faraji F, Osazuwa-Peters N, Walker RJ, Ward GM Abstract OBJECTIVES: The impact of positive tumor margin status and other clinicopathological factors on prognosis in early stage glottic squamous cell carcinoma (SCC) treated with transoral laser microsurgery...
Wed Jul 01, 2020 16:10
Transoral 980-nm/1470-nm dual-wavelength fiber laser microsurgery for early-stage glottic carcinoma.
Related Articles Transoral 980-nm/1470-nm dual-wavelength fiber laser microsurgery for early-stage glottic carcinoma. Oral Oncol. 2019 09;96:66-70 Authors: Liang F, Xiao Z, Chen R, Han P, Lin P, Huang Y, Huang X Abstract OBJECTIVES: To investigate the effective and safety of transoral 980-nm/1470-nm dual-wavelength fiber laser microsurgery for early-stage glottic carcinoma by compared with CO2 laser surgery. MATERIALS AND METHODS:...
Wed Jul 01, 2020 16:10
Related Articles Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold. Laryngoscope. 2020 01;130(1):E21-E29 Authors: Nagubothu SR, Sugars RV, Tudzarovski N, Andrén AT, Bottai M, Davies LC, Hertegård S, Le Blanc K Abstract OBJECTIVES/HYPOTHESIS: This study aimed to determine whether local injection of human mesenchymal stromal cells (MSC) could modulate the early inflammatory response within injured vocal...
Wed Jul 01, 2020 16:10
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